1268686-81-2Relevant academic research and scientific papers
Method for synthesizing five-membered ring lactone compound from carbon dioxide in air
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Paragraph 0037; 0038; 0039; 0040, (2016/11/17)
The invention discloses a method for synthesizing a five-membered ring lactone compound from carbon dioxide in air. 1 mmol of terminal alkyne and 5-10 folds of anhydrous tetrahydrofuran are added to a dry flask under protection of nitrogen gas, 1.0 equivalent weight of n-butylithium is added at the temperature of subzero 78 DEG C, air dried by anhydrous calcium chloride is pumped into a reaction liquid by a pressure pump after 1 h and is stopped from pumping in 8-10 h, 1.0 equivalent weight of an alpha-halogenate carbonyl compound and 2.0 equivalent weight of potassium carbonate are added under protection of nitrogen gas, the mixture reacts for 3-10 h at the temperature of 100 DEG C, and the reaction is tracked through TLC (thin layer chromatography). After the mixture sufficiently reacts, the mixture is cooled to the room temperature and filtered, a solvent is removed under reduced pressure, and a product is obtained through quick silica column chromatographic purification. According to the novel method for synthesizing the five-membered ring lactone compound, carbon dioxide in the air can be absorbed, the greenhouse effect is reduced, and a series of serious problems such as global climate warming and the like caused by the greenhouse effect can be reduced. Raw materials required in the experiment are easy to obtain, the yield is high, and the application prospect is wide.
Base-mediated tandem reaction consisting of an acyl shift strategy leading to 4,5-disubstiuted furan-2(5H)-ones
Lei, Yong,Wang, Zhi-Qiang,Xie, Ye-Xiang,Yu, Shang-Ci,Tang, Bo-Xiao,Li, Jin-Heng
supporting information; experimental part, p. 31 - 35 (2011/03/20)
The first example of the synthesis of 4,5-disubstiuted furan-2(5H)-ones by base-mediated tandem acyl shift/cyclization/decarbonylation reactions of aroylmethyl 2-alkynoates has been developed. This new and inexpensive tandem route allows both a C-O bond a
