1268821-08-4

Basic information

• Product Name: 4-(4-methoxyphenyl)-1,1-dimethylpiperazin-1-ium chloride
• Synonyms: 4-(4-methoxyphenyl)-1,1-dimethylpiperazin-1-ium chloride
• CAS NO: 1268821-08-4
• Molecular Weight: 256.776
• Mol File: 1268821-08-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-methoxyphenyl)-1,1-dimethylpiperazin-1-ium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methoxyphenyl)-1,1-dimethylpiperazin-1-ium chloride(1268821-08-4)
• EPA Substance Registry System: 4-(4-methoxyphenyl)-1,1-dimethylpiperazin-1-ium chloride(1268821-08-4)

Safety Data

• Hazardous Substances Data: 1268821-08-4(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 1448-52-8 N,N-bis(2-chloroethyl)-4-methoxybenzenamine 
• 124-40-3 dimethyl amine 
• 19721-54-1 2-[(2-hydroxyethyl)-(4-methoxyphenyl)amino]ethanol 

Relevant articles and documents

Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)

A series of monospirocyclopiperazinium salts were designed and synthesized to search for a peripherally-acting analgesic drug with low side effects. Extensive SAR studies revealed that a suitable NR2R3 was critical for the analgesic activity, which might be beneficial to expose the cationic nitrogen to bind to the receptor, and possibly interact with the receptor via π-π interaction. Introduction of substituting group on the N4-phenyl ring could improve the activity, and the best position was the 4-position. Compound 14n showed more potent analgesic activity (63%, 20 μM/kg, sc) and holds promise for development as a mechanically new analgesic drug.