126891-21-2

Upstream product

• 163431-76-3 (2S,4R)-4-tert-butyldimethylsiloxypyrrolidine-2-carboxylic acid 
• 126891-22-3 (R)-4-(tert-Butyl-dimethyl-silanyloxy)-4,5-dihydro-3H-pyrrole-2-carboxylic acid benzyl ester 
• 89813-47-8 N-(tert-butoxycarbonyl)-(2S,4R)-4-hydroxyproline benzyl ester 
• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 126891-19-8 (2S,3S,4S)-4-(2-Hydroxy-phenyl)-3-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 74-88-4 methyl iodide 
• 51-35-4 4R-4-hydroxyproline 
• 135388-20-4 (3aR,4S,6aR)-2-Ethoxy-hexahydro-furo[2,3-c]pyrrole-4,5-dicarboxylic acid 4-benzyl ester 5-ethyl ester 
• 135388-20-4 (3aR,6aR)-2-Ethoxy-hexahydro-furo[2,3-c]pyrrole-4,5-dicarboxylic acid 4-benzyl ester 5-ethyl ester 
• 135388-17-9 (2S,3R,4R)-3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-(toluene-4-sulfonyloxy)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester 
• 126891-25-6 (2S,3R,4R)-3-(2-Hydroxy-ethyl)-4-(toluene-4-sulfonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-ethyl ester 
• 126891-23-4 (R)-4-(2-Bromo-1-ethoxy-ethoxy)-4,5-dihydro-pyrrole-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester 
• 135388-13-5 (R)-4-(tert-Butyl-dimethyl-silanyloxy)-4,5-dihydro-pyrrole-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester 
• 135388-21-5 (2S,3S,4S)-3-(2-Hydroxy-ethyl)-4-(2-methoxy-phenyl)-pyrrolidine-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester 

Downstream Products

• 132785-33-2 MFPA 

Relevant academic research and scientific papers

Synthesis of new acromelic acid congeners: Novel neuroexcitatory amino acids acting on glutamate receptor

A general synthetic method of acromelic acid congeners was developed. Various C4-substituents of this family was introduced by the substitution reaction of the corresponding tosylate with diaryl copper lithium. Phenyl derivative 11 showed comparable excitatory activity with kainic acid, and o-anisyl derivative 12 had most potent activity in this family.

Simple analogs of acromelic acid, which are highly active agonists of kainate type neuroexcitant

The highly stereoselective synthesis of acromelic acid analogs; 3a and 3b, was achieved. The new kainoid 3b was found to be the strongest neuroexcitant among the kainoids known so far.