135388-20-4

Upstream product

• 89813-47-8 N-(tert-butoxycarbonyl)-(2S,4R)-4-hydroxyproline benzyl ester 
• 51-35-4 4R-4-hydroxyproline 
• 126891-23-4 (R)-4-(2-Bromo-1-ethoxy-ethoxy)-4,5-dihydro-pyrrole-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester 
• 135388-13-5 (R)-4-(tert-Butyl-dimethyl-silanyloxy)-4,5-dihydro-pyrrole-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester 
• 163431-76-3 (2S,4R)-4-tert-butyldimethylsiloxypyrrolidine-2-carboxylic acid 
• 126891-22-3 (R)-4-(tert-Butyl-dimethyl-silanyloxy)-4,5-dihydro-3H-pyrrole-2-carboxylic acid benzyl ester 
• 100-44-7 benzyl chloride 
• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 135388-20-4 (3aR,6aR)-2-Ethoxy-hexahydro-furo[2,3-c]pyrrole-4,5-dicarboxylic acid 4-benzyl ester 5-ethyl ester 

Downstream Products

• 135388-20-4 (3aR,4S,6aR)-2-Ethoxy-hexahydro-furo[2,3-c]pyrrole-4,5-dicarboxylic acid 4-benzyl ester 5-ethyl ester 
• 126891-24-5 (3aR,4S,6aR)-2-Oxo-hexahydro-furo[2,3-c]pyrrole-4,5-dicarboxylic acid 4-benzyl ester 5-ethyl ester 
• 135388-17-9 (2S,3R,4R)-3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-(toluene-4-sulfonyloxy)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester 
• 126891-25-6 (2S,3R,4R)-3-(2-Hydroxy-ethyl)-4-(toluene-4-sulfonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-ethyl ester 
• 135388-23-7 (2S,3S,4S)-4-(2,4-Dimethoxy-phenyl)-3-(2-hydroxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester 
• 135388-21-5 (2S,3S,4S)-3-(2-Hydroxy-ethyl)-4-(2-methoxy-phenyl)-pyrrolidine-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester 
• 135388-22-6 (2S,3S,4S)-3-(2-Hydroxy-ethyl)-4-(4-methoxy-phenyl)-pyrrolidine-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester 
• 126891-26-7 (2S,3S,4S)-3-(2-Hydroxy-ethyl)-4-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester 
• 135388-19-1 (2S,3S,4S)-3-Carboxymethyl-4-(2,4-dimethoxy-phenyl)-pyrrolidine-2-carboxylic acid 
• 135388-16-8 (2S,3R,4R)-4-Hydroxy-3-(2-hydroxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester 
• 135388-18-0 (2S,3S,4S)-3-methylenecarboxy-4-(4-methoxyphenyl)pyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of new acromelic acid congeners: Novel neuroexcitatory amino acids acting on glutamate receptor

A general synthetic method of acromelic acid congeners was developed. Various C4-substituents of this family was introduced by the substitution reaction of the corresponding tosylate with diaryl copper lithium. Phenyl derivative 11 showed comparable excitatory activity with kainic acid, and o-anisyl derivative 12 had most potent activity in this family.