126920-19-2Relevant academic research and scientific papers
Asymmetric Cycloisomerization of o-Alkenyl-N-Methylanilines to Indolines by Iridium-Catalyzed C(sp3)?H Addition to Carbon–Carbon Double Bonds
Torigoe, Takeru,Ohmura, Toshimichi,Suginome, Michinori
, p. 14272 - 14276 (2017)
Highly enantioselective cycloisomerization of N-methylanilines, bearing o-alkenyl groups, into indolines is established. An iridium catalyst bearing a bidentate chiral diphosphine effectively promotes the intramolecular addition of the C(sp3)?H bond across a carbon–carbon double bond in a highly enantioselective fashion. The reaction gives indolines bearing a quaternary stereogenic carbon center at the 3-position. The reaction mechanism involves rate-determining oxidative addition of the N-methyl C?H bond, followed by intramolecular carboiridation and subsequent reductive elimination.
Nitrogen Assistance in Intramolecular Nickel-Promoted Tandem Cyclization-Quenching Processes
Sole, Daniel,Cancho, Yolanda,Llebaria, Amadeu,Moreto, Josep M.,Delgado, Antonio
, p. 5895 - 5904 (1996)
A diastereoselective and mild cyclization-quenching process based on the treatment of nitrogen-tethered halodienes with stoichiometric Ni(COD)2 is described. The success of this methodology relies on the presence of a distal amino group capable of coordin
Synthesis of indolines via a photocatalytic intramolecular reductive cyclization reaction
Yamaguchi, Eiji,Goto, Yumiko,Itoh, Akichika
, p. 177 - 185 (2020/02/04)
– Herein, we synthesized a series of indolines using a photocatalytic intramolecular reductive cyclization reaction. This reaction uses several N-allyl-2-iodoanilines in the presence of 10-phenylphenothiazine (Ph-PTZ) as an organic photocatalyst. Further,
