1269425-69-5

Basic information

• Product Name: (2S)-tert-butyl 5-hydroxy-1-tosylpyrrolidine-2-carboxylate
• Synonyms: (2S)-tert-butyl 5-hydroxy-1-tosylpyrrolidine-2-carboxylate
• CAS NO: 1269425-69-5
• Molecular Weight: 341.428
• Mol File: 1269425-69-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S)-tert-butyl 5-hydroxy-1-tosylpyrrolidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-tert-butyl 5-hydroxy-1-tosylpyrrolidine-2-carboxylate(1269425-69-5)
• EPA Substance Registry System: (2S)-tert-butyl 5-hydroxy-1-tosylpyrrolidine-2-carboxylate(1269425-69-5)

Safety Data

• Hazardous Substances Data: 1269425-69-5(Hazardous Substances Data)

Upstream product

• 127700-63-4 (2S)-(N-para-toluenesulphonylamino)pentanoic acid tert-butyl ester 
• 21957-65-3 1-(4'-methylbenzenesulfonyl)-5-oxopyrrolidine-2-carboxylic acid 
• 4816-80-2 N-tosyl-L-glutamic acid 
• 56-86-0 L-glutamic acid 
• 463962-06-3 tert-butyl (2S)-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinecarboxylate 
• 35418-16-7 L-t-butyl pyroglutamate 
• 540-88-5 acetic acid tert-butyl ester 

Downstream Products

• 1269425-79-7 (1R,4S,7S)-tert-butyl 3-tosyl-8-oxa-3-azabicyclo[5.1.0]octane-4-carboxylate 

Relevant articles and documents

Chemoselective Intramolecular Functionalization of Methyl Groups in Nonconstrained Molecules Promoted by N-Iodosulfonamides

Mechanistic evidence observed in Hofmann-L?ffler-Freytag-type reactions has been crucial to achieve the chemoselective functionalization of methyl groups under mild conditions. Radical-mediated methyl iodination and subsequent oxidative deiodination are the key steps in this functionalization, where iodine chemistry has a pivotal role on the formation of the C-N bond. The concepts of single hydrogen atom transfer (SHAT) and multiple hydrogen atom transfer (MHAT) are introduced to describe the observed chemoselectivity. (Chemical Equation Presented).