463962-06-3

Basic information

• Product Name: tert-butyl (2S)-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinecarboxylate
• Synonyms: tert-butyl (2S)-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinecarboxylate
• CAS NO: 463962-06-3
• Molecular Weight: 339.412
• Mol File: 463962-06-3.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl (2S)-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2S)-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinecarboxylate(463962-06-3)
• EPA Substance Registry System: tert-butyl (2S)-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinecarboxylate(463962-06-3)

Safety Data

• Hazardous Substances Data: 463962-06-3(Hazardous Substances Data)

Upstream product

• 4816-80-2 N-tosyl-L-glutamic acid 
• 56-86-0 L-glutamic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 21957-65-3 1-(4'-methylbenzenesulfonyl)-5-oxopyrrolidine-2-carboxylic acid 
• 127700-63-4 (2S)-(N-para-toluenesulphonylamino)pentanoic acid tert-butyl ester 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 35418-16-7 L-t-butyl pyroglutamate 
• 98-59-9 p-toluenesulfonyl chloride 
• 540-88-5 acetic acid tert-butyl ester 

Downstream Products

• 94429-50-2 N-Tosyl-L-glutaminsaeure-1-tert.-butylester-5-amid 
• 88637-19-8 N-Tosyl-L-glutaminsaeure-1-tert.-butylester-5-hydrazid 
• 94430-73-6 N-Tosyl-L-glutaminsaeure-1-tert.-butylester 
• 105002-40-2 N-(N-Tosyl-L-γ-glutamyl-1-tert.-butylester)-S-benzyl-L-cystein-methylester 
• 1269425-69-5 (2S)-tert-butyl 5-hydroxy-1-tosylpyrrolidine-2-carboxylate 
• 1269425-79-7 (1R,4S,7S)-tert-butyl 3-tosyl-8-oxa-3-azabicyclo[5.1.0]octane-4-carboxylate 
• 1254719-17-9 (S)-tert-butyl 1-tosylpyrrolidine-2-carboxylate 

Relevant articles and documents

Chemoselective Intramolecular Functionalization of Methyl Groups in Nonconstrained Molecules Promoted by N-Iodosulfonamides

Mechanistic evidence observed in Hofmann-L?ffler-Freytag-type reactions has been crucial to achieve the chemoselective functionalization of methyl groups under mild conditions. Radical-mediated methyl iodination and subsequent oxidative deiodination are the key steps in this functionalization, where iodine chemistry has a pivotal role on the formation of the C-N bond. The concepts of single hydrogen atom transfer (SHAT) and multiple hydrogen atom transfer (MHAT) are introduced to describe the observed chemoselectivity. (Chemical Equation Presented).

Remote chiral induction in vinyl sulfonium salt-mediated ring expansion of hemiaminals into epoxide-fused azepines

The planet of the azepines: Epoxy-fused azepines have been synthesized in a highly selective reaction with hemiaminals and vinyl sulfonium salts. Stereochemistry is controlled by the substituent at the four- or five-position of the hemiaminal. The key step involves ring-opening of the hemiaminal, conjugate addition onto a vinyl sulfonium salt, and epoxidation of the aldehyde by the in situ formed sulfur ylide. Copyright