1269467-56-2Relevant articles and documents
Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells
Pierre, Fabrice,Regan, Collin F.,Chevrel, Marie-Claire,Siddiqui-Jain, Adam,MacAlino, Diwata,Streiner, Nicole,Drygin, Denis,Haddach, Mustapha,O'Brien, Sean E.,Rice, William G.,Ryckman, David M.
, p. 3327 - 3331 (2012/06/18)
A novel family of potent dual inhibitors of CK2 and the Pim kinases was discovered by modifying the scaffolds of tricyclic Pim inhibitors. Several analogs were active at single digit nanomolar IC50 values against CK2 and the Pim isoforms Pim-1