1270008-56-4Relevant articles and documents
Synthesis of novel 1-hydroxyquinolones with high anti-toxoplasma activity
Tietze, Lutz F.,Ma, Ling
, p. 377 - 396 (2011/04/24)
All for the treatment of malaria and toxoplasmosis the novel hydroxyquinolones 2-5 were prepared by reaction of aniline and hydroxyaniline, respectively and the β-ketoesters 10a-c. As products the quinolones 8 and 15, respectively were obtained. Benzylation, oxidation and hydrogenation then led to the desired substances. Compound 2 has a similar anti-malaria activity as the approved drug Atovaquone. The Japan Institute of Heterocyclic Chemistry.