1270044-39-7Relevant academic research and scientific papers
Site-selective C-H/C-N activation by cooperative catalysis: Primary amides as arylating reagents in directed C-H arylation
Meng, Guangrong,Szostak, Michal
, p. 7251 - 7256 (2017)
Direct C-H arylation of nonacidic C(sp)-H bonds with primary amides as arylating reagents via highly chemoselective C-H/C-N/C-C cleavages has been accomplished for the first time. The key to the success is the cooperative combination of rhodium(I) catalys
Expeditious and Solvent-Free Nickel-Catalyzed C?H Arylation of Arenes and Indoles
Jagtap, Rahul A.,Soni, Vineeta,Punji, Benudhar
, p. 2242 - 2248 (2017/05/29)
An efficient solvent-free nickel-catalyzed method for C?H bond arylation of arenes and indoles has been developed, which proceeds expeditiously through chelation assistance. The reaction is highly selective for mono-arylation and tolerates sensitive and structurally diverse functionalities, such as halides, ethers, amines, indole, pyrrole and carbazole. This reaction represents the first example of a nickel-catalyzed C?H arylation by monochelate assistance and symbolizes a rare precedent in solvent-free C?H arylation. Mechanistic investigations by various controlled reactions, kinetic studies, and deuterium labeling experiments suggest that the arylation follows a single electron transfer (SET) pathway involving the turnover-limiting C?H nickelation process.
Room-temperature chromium(II)-catalyzed direct arylation of pyridines, aryl oxazolines, and imines using arylmagnesium reagents
Kuzmina, Olesya M.,Knochel, Paul
supporting information, p. 5208 - 5211 (2015/01/08)
We report a CrCl2-catalyzed oxidative arylation of various pyridines, aryl oxazolines, and aryl imines using aromatic Grignard reagents in the presence of 2,3-dichlorobutane (DCB). Most of the reactions proceed rapidly at 25 °C and do not requi
Direct cross-coupling of C-H bonds with grignard reagents through cobalt catalysis
Li, Bin,Wu, Zhen-Hua,Gu, Yi-Fan,Sun, Chang-Liang,Wang, Bai-Quan,Shi, Zhang-Jie
supporting information; experimental part, p. 1109 - 1113 (2011/04/22)
Go go Grignard! The first highly regioselective, cobalt-catalyzed C-H transformation of benzo[h]quinoline and phenylpyridine derivatives with Grignard reagents at room temperature has been achieved (see scheme). Both aryl and alkyl Grignard reagents showed significant reactivity.
