Welcome to LookChem.com Sign In|Join Free

CAS

  • or

127034-05-3

(2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

127034-05-3 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 127034-05-3 Structure

  • Basic information

    1. Product Name: (2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one
    2. Synonyms: (2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one
    3. CAS NO:127034-05-3
    4. Molecular Formula:
    5. Molecular Weight: 343.336
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 127034-05-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one(127034-05-3)
    11. EPA Substance Registry System: (2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one(127034-05-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 127034-05-3(Hazardous Substances Data)

127034-05-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 127034-05-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,0,3 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 127034-05:
(8*1)+(7*2)+(6*7)+(5*0)+(4*3)+(3*4)+(2*0)+(1*5)=93
93 % 10 = 3
So 127034-05-3 is a valid CAS Registry Number.

127034-05-3Downstream Products

127034-05-3Relevant articles and documents

Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies

Bai, Ruoli,Biagioni, Stefano,Cavallini, Chiara,Coluccia, Addolorata Maria Luce,Coluccia, Antonio,Da Pozzo, Eleonora,Hamel, Ernest,La Regina, Giuseppe,Liu, Te,Martini, Claudia,Mazzoccoli, Carmela,Mazzoni, Cristina,Nalli, Marianna,Orlando, Viviana,Puxeddu, Michela,Shen, Hongliang,Silvestri, Romano

, (2019)

Novel 3-aroyl-1,4-diarylpyrrole derivatives were synthesized to explore structure-activity relationships at the phenyls at positions 1 and 4 of the pyrrole. The presence of amino phenyl rings at positions 1 and 4 of the pyrrole ring were found to be a crucial requirement for potent antitumor activity. Several compounds strongly inhibited tubulin assembly through binding to the colchicine site. Compounds 42, 44, 48, 62 and 69 showed antitumor activity with low nanomolar IC50 values in several cancer cell lines. Compound 48 was generally more effective as an inhibitor of glioblastoma, colorectal and urinary bladder cancer cell lines; 69 consistently inhibited CML cell lines and demonstrated superiority in nilotinib and imatinib resistant LAMA84-R and KBM5-T315I cells. In animal models, compound 48 exhibited significant inhibition of the growth of T24 bladder carcinoma and ES-2 ovarian clear cell carcinoma tumors. Compounds 48 and 69 represent robust lead compounds for the design of new broad-spectrum anticancer agents active in different types of solid and hematological tumors.

Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors

Salum, Lívia B.,Altei, Wanessa F.,Chiaradia, Louise D.,Cordeiro, Marlon N.S.,Canevarolo, Rafael R.,Melo, Carolina P.S.,Winter, Evelyn,Mattei, Bruno,Daghestani, Hikmat N.,Santos-Silva, Maria Cláudia,Creczynski-Pasa, Tania B.,Yunes, Rosendo A.,Yunes, José A.,Andricopulo, Adriano D.,Day, Billy W.,Nunes, Ricardo J.,Vogt, Andreas

supporting information, p. 501 - 510 (2013/07/25)

Based on classical colchicine site ligands and a computational model of the colchicine binding site on beta tubulin, two classes of chalcone derivatives were designed, synthesized and evaluated for inhibition of tubulin assembly and toxicity in human canc

Chalcones: A new class of antimitotic agents

Edwards,Stemerick,Sunkara

, p. 1948 - 1954 (2007/10/02)

A series of chalcones was evaluated as antimitotic agents. One of these, (E)-1-(2,5-dimethoxyphenyl)-3-[4-(dimethylamino)phenyl]-2-methyl-2-propen- 1-one) (73), was found to be an effective antimitotic agent at a concentration of 4 nM in an in vitro HeLa

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 127034-05-3