127047-06-7

Upstream product

• 877077-49-1 (R)-(+)-2-(methoxycarbonyl)-2-(4-methylphenyl)propionic acid 
• 127047-04-5 dimethyl 2-methyl-2-(4-methylphenyl)malonate 
• 79443-97-3 methyl 2-(4-methylphenyl)propanoate 

Downstream Products

• 127047-08-9 (S)-2-Methyl-2-p-tolyl-malonic acid monomethyl ester 

Relevant academic research and scientific papers

Reverse chemoselective borane reduction of an optically active malonic acid ester

Reduction of the 2-methyl-2-p-tolylmalonic monoester (+)-2 with the borane-dimethylsulfide complex took place unexpectedly on the ester function, providing the β-hydroxy-acid (-)-3. This chemoselective reaction proceeded likely through formation of a six-

Asymmetric Construction of Quaternary Carbons from Chiral Malonates: Selective and Versatile Total Syntheses of the Enantiomers of α- and β-Cuparenones from a Common Optically Active Precursor

From a single chiron (R)-4, available with high enantiomeric purity (96percent) by simple enzymatic hydrolysis (PLE) of a prochiral malonate, were prepared convenient precursors of the two enantiomers of α- and β-cuparenones (1a,b and 2a,b).This versatile