Reverse chemoselective borane reduction of an optically active malonic acid ester

DOI: 10.1016/S0040-4039(00)70651-4

Source and publish data:

Tetrahedron Letters p. 6687 - 6690 (1989)

Update date:2022-08-04

Topics:

Authors:

Fadel Fadel

Canet Canet

Salaun Salaun

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Article abstract of DOI:10.1016/S0040-4039(00)70651-4

Reduction of the 2-methyl-2-p-tolylmalonic monoester (+)-2 with the borane-dimethylsulfide complex took place unexpectedly on the ester function, providing the β-hydroxy-acid (-)-3. This chemoselective reaction proceeded likely through formation of a six-

Full text of DOI:10.1016/S0040-4039(00)70651-4

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