877077-49-1

Upstream product

• 79443-97-3 methyl 2-(4-methylphenyl)propanoate 
• 127047-04-5 dimethyl 2-methyl-2-(4-methylphenyl)malonate 

Downstream Products

• 127047-09-0 (S)-3-Methoxycarbonyloxy-2-methyl-3-oxo-2-p-tolyl-propionic acid methyl ester 
• 127047-08-9 (S)-2-Methyl-2-p-tolyl-malonic acid monomethyl ester 
• 133678-80-5 (R)-(+)-methyl 4-diazo-2-methyl-2-(4-methylphenyl)-3-oxobutanoate 
• 141116-75-8 (2R,3R)-3-hydroxy-2-methyl-2-(4-methylphenyl)-4-butanolide 
• 141045-53-6 (2R,3S)-3-hydroxy-2-methyl-2-(4-methylphenyl)-4-butanolide 
• 141045-53-6 (2R,3R/S)-3-hydroxy-2-methyl-2-(4-methylphenyl)-4-butanolide 
• 141045-50-3 (3S)-(-)-3-methyl-3-(4-methylphenyl)pentane-1,4-diol 
• 141045-50-3 (3S)-(+)-3-methyl-3-(4-methylphenyl)pentane-1,4-diol 
• 133678-92-9 (2R)-(-)-2-methyl-2-(4-methylphenyl)pentane-1,4-diol 
• 133678-92-9 (2R)-(+)-2-methyl-2-(4-methylphenyl)pentane-1,4-diol 
• 141116-74-7 (S)-(-)-2-methyl-2-(4-methylphenyl)-4-butanolide 
• 141045-58-1 (R)-(+)-2-methyl-2-(4-methylphenyl)-3-<<(4-methylphenyl)sulfonyl>hydrazono>-4-butanolide 
• 133678-88-3 (R)-(+)-methyl 2-methyl-2-(4-methylphenyl)-3-(tosyloxy)propionate 
• 141045-56-9 (2R,3S)-(+)-2-methyl-2-(4-methylphenyl)-3-(mesyloxy)-4-butanolide 

Relevant academic research and scientific papers

Asymmetric Construction of Quaternary Carbons from Chiral Malonates: Selective and Versatile Total Syntheses of the Enantiomers of α- and β-Cuparenones from a Common Optically Active Precursor

From a single chiron (R)-4, available with high enantiomeric purity (96percent) by simple enzymatic hydrolysis (PLE) of a prochiral malonate, were prepared convenient precursors of the two enantiomers of α- and β-cuparenones (1a,b and 2a,b).This versatile

Enzymes in organic synthesis 50. Probing the dimensions of the large hydrophobic binding region of the active site of pig liver esterase using substituted aryl malonate substrates

The active side model reported recently for the synthetically useful enzyme pig liver esterase (PLE) permits the structural specificity and stereoselectivity of the enzyme to be interpreted and predicted for a wide range of substrates. The specifications

Reverse chemoselective borane reduction of an optically active malonic acid ester

Reduction of the 2-methyl-2-p-tolylmalonic monoester (+)-2 with the borane-dimethylsulfide complex took place unexpectedly on the ester function, providing the β-hydroxy-acid (-)-3. This chemoselective reaction proceeded likely through formation of a six-