1270475-03-0 Usage
Chemical Classification
Heterocyclic amine
Source
Found in cooked meat and tobacco smoke
Formation
Occurs during the cooking process of meat, especially at high temperatures
Carcinogenicity
Known carcinogen
Potency
One of the most potent mutagenic and carcinogenic compounds in cooked meat
Health Risks
Linked to increased risk of colorectal and breast cancers
Potential contributor to various other types of cancers
DNA Damage
Potent inducer of DNA damage
Regulatory Measures
Efforts to reduce levels in cooked meat products and raise awareness about associated health risks
Check Digit Verification of cas no
The CAS Registry Mumber 1270475-03-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,7,0,4,7 and 5 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1270475-03:
(9*1)+(8*2)+(7*7)+(6*0)+(5*4)+(4*7)+(3*5)+(2*0)+(1*3)=140
140 % 10 = 0
So 1270475-03-0 is a valid CAS Registry Number.
1270475-03-0Relevant articles and documents
Discovery of (S)-1-(1-(Imidazo[1,2- a ]pyridin-6-yl)ethyl)-6-(1-methyl-1 H -pyrazol-4-yl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer
Jia, Hong,Dai, Guangxiu,Weng, Jianyang,Zhang, Zhulin,Wang, Qing,Zhou, Feng,Jiao, Longxian,Cui, Yumin,Ren, Yongxin,Fan, Shiming,Zhou, Jinghong,Qing, Weiguo,Gu, Yi,Wang, Jian,Sai, Yang,Su, Weiguo
supporting information, p. 7577 - 7589 (2014/12/11)
HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure-activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.
