944905-12-8

Basic information

• Product Name: 1-IMidazo[1,2-a]pyridin-6-ylethanone
• Synonyms: 1-IMidazo[1,2-a]pyridin-6-ylethanone;1-(imidazo[1,2-a]pyridin-6-yl)ethan-1-one;EOS-60801
• CAS NO: 944905-12-8
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.17262
• EINECS: -0
• Mol File: 944905-12-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 5.14±0.50(Predicted)
• CAS DataBase Reference: 1-IMidazo[1,2-a]pyridin-6-ylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-IMidazo[1,2-a]pyridin-6-ylethanone(944905-12-8)
• EPA Substance Registry System: 1-IMidazo[1,2-a]pyridin-6-ylethanone(944905-12-8)

Safety Data

• Hazardous Substances Data: 944905-12-8(Hazardous Substances Data)

Usage

General Description

1-IMidazo[1,2-a]pyridin-6-ylethanone is a chemical compound with the molecular formula C10H8N2O. It is a heterocyclic compound with a bicyclic structure containing both an imidazole and pyridine ring. 1-IMidazo[1,2-a]pyridin-6-ylethanone is commonly utilized as a building block in the synthesis of various pharmaceutical compounds and organic materials due to its versatile reactivity and ability to participate in a wide range of chemical reactions. It has also been studied for its potential pharmacological properties and biological activities, making it an important molecule in the field of medicinal chemistry and drug development. Additionally, its unique structural features make it valuable for the development of new materials with specific electronic and optoelectronic properties.

Upstream product

• 139022-25-6 imidazo[1,2-a]pyridine-6-carboxylic acid 
• 3167-49-5 6-aminonicotinic acid 
• 136117-69-6 methyl 6-imidazo<1,2-a>pyridinecarboxylate 
• 36052-24-1 methyl 6-aminonicotinoate 
• 1313726-20-3 imidazo[1,2-a]pyridine-6-carboxylic acid methoxy(methyl)amide 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1270475-03-0 1-(imidazo[1,2-a]pyridin-6-yl)ethanamine 
• 1313725-89-1 (R)-1-(1-(imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine 
• 1313725-88-0 savolitinib 

Relevant articles and documents

PROCESS FOR PREPARATION OF SAVOLITINIB AND ITS INTERMEDIATES

The present application relates to a process for preparation of chiral amine fragment (IV) of savolitinib. The present application also relates to a process for preparation of savolitinib using the chiral amine (IV), as prepared by the process of the present application. The present application also discloses new intermediates useful for the synthesis of savolitinib. The present application further relates to crystalline forms of savolitinib, namely AA1, formic acid solvate and AA2. The present application also relates to amorphous solid dispersion of savolitinib.

Discovery of (S)-1-(1-(Imidazo[1,2- a ]pyridin-6-yl)ethyl)-6-(1-methyl-1 H -pyrazol-4-yl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer

HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure-activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.