127072-98-4

Upstream product

• 99-20-7 TREHALOSE 
• 42390-78-3 2,3,4,6,2',3',4',6'-octa-O-trimethylsilyl-α,α-D-trehalose 
• 108-24-7 acetic anhydride 
• 127072-92-8 3,3'-di-o-benzyl-4,6,4',6'-di-o-benzylidene-α,α'-D-trehalose 

Relevant academic research and scientific papers

TMSOTf-catalyzed silylation: Streamlined regioselective one-pot protection and acetylation of carbohydrates

A highly efficient TMSOTf-catalyzed HMDS silylation of sugars, which can easily be integrated with subsequent reactions in one-pot fashion, has been developed. Its usefulness was demonstrated by applications to streamlined regioselective one-pot protection and nonenzymatic acetylation of unprotected sugars. Monosaccharide and trehalose building blocks with orthogonally well-differentiated hydroxy groups were efficiently prepared starting with free sugars in one-pot fashion without the need for prior per-O-silylation. Regioselectively protected and acetylated building blocks were prepared directly from unprotected sugars in a one-pot manner involving up to five TMSOTf-catalyzed reactions, including a new TMSOTf-catalyzed silylation of carbohydrates. Copyright

Iron(iii) chloride-tandem catalysis for a one-pot regioselective protection of glycopyranosides

Tandem catalysis by using iron(iii) chloride hexahydrate leads to carbohydrate building blocks displaying an orthogonal protecting group pattern as illustrated by the regioselective protection of trehalose and maltose disaccharides.