127084-38-2Relevant academic research and scientific papers
Formal total synthesis of nikkomycin B based on a lipase-catalysed hydrolysis of an acetate possessing two stereogenic centers
Akita, Hiroyuki,Chen, Cheng Yu,Kato, Keisuke
, p. 11011 - 11026 (2007/10/03)
A stereoselective synthesis of the versatile chiral synthon possessing two stereogenic centers, (2S,3S)-11 (>99% ee) was achieved by using chemo- enzymatic method. The conversion of (2S,3s)-11 into the homochiral intermediates (2S,3S,4S)-25 and (2S,3S,4S)-27 corresponding to the N-terminal amino acid moiety of nikkomycin B(1) and their application to the formal total synthesis of nikkomycin B(1) are described.
A formal total synthesis of nikkomycin B based on enzymatic resolution of a primary alcohol possessing two stereogenic centers
Akita,Chen,Uchida
, p. 2131 - 2134 (2007/10/03)
A highly stereoselective synthesis of the versatile chiral synthon possessing two stereogenic centers, (2S,3S)-8 (>99% ee) was achieved and the conversion of (2S,3S)-8 into the homochiral intermediate (2S,3S,4S)-1 for the synthesis of nikkomycin B is described.
Applications of Crotyldiisopinocampheylboranes in Synthesis: The Total Synthesis of Nikkomycin B
Barrett, Anthony G. M.,Lebold, Suzanne A.
, p. 4875 - 4884 (2007/10/02)
(-)-(E)-Crotyldiisopinocampheylborane was employed in a highly diastereoselective and enantioselective synthesis of the γ-hydroxy-β-methyl-α-aminobutanoic acid moiety of nikkomycin B.A protected derivative of this N-terminal amino acid residue was condens
