127133-29-3Relevant academic research and scientific papers
Electrophilic Olefin Heterocyclization in Organic Synthesis. Highly Stereoselective Synthesis of Trans 3,5-Disubstituted Pyrrolidin-2-ones by Iodolactamization via Homoallylic Asymmetric Induction
Takahata, Hiroki,Takamatsu, Tamotsu,Chen, Yin-Shan,Ohkubo, Naoki,Yamazaki, Takao,et al.
, p. 3792 - 3797 (2007/10/02)
α-Substituted γ,δ-unsaturated thioimidates 19-24, prepared by methylation of the corresponding thioamides 13-18, undergo iodine-induced lactamization to provide the 3,5-disubstituted pyrrolidin-2-ones 25a,b-30a,b.High 1,3-asymmetric induction by the homoa
IODINE-INDUCED IMINOTHIOLACTONIZATION OF γ,δ-UNSATURATED SECONDARY THIOAMIDES, NEW ENTRY TO 2-ACETOAMIDOTHIOPHENES
Takahata, Hiroki,Suzuki, Toshiaki,Maruyama, Mihoko,Moriyama, Keiko,Mozumi, Mayumi,et.al.
, p. 4777 - 4786 (2007/10/02)
Iodine-induced cyclization of γ,δ-unsaturated secondary thioamides 1 proceeded regio- (5-exo-trigonal) and chemo- (sulfur-carbon bond formation)selectively, providing iminothiolactones 2, which were converted in two-step sequences (dehydroiodination and N-acetylation) into 2-acetoamidothiophenes 4.This procedure was performed in one flask to afford polysubstituted 2-aminothiophenes.
