58377-03-0Relevant academic research and scientific papers
Dehydrative Beckmann rearrangement and the following cascade reactions
Liu, Yinghui,Wei, Yongjiao,Xie, Lan-Gui
, (2021/11/16)
The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam. By strategically using the in situ generated Appel's salt or Mitsunobu's zwitterionic adduct as the dehydrating agent, a series of Beckmann rearrangement and following cascade reactions have been developed herein. The protocol allows the conversion of various ketoximes into amide, thioamide, tetrazole and imide products in modular procedures. The generality and tolerance of functionalities of this method have been demonstrated.
Method for synthesizing thioamide compound from 1,2,3-thiodiazole compound and amine under catalysis of copper
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Paragraph 0089-0095, (2021/05/12)
The invention belongs to the technical field of organic chemistry, and discloses a method for synthesizing a thioamide compound from a 1,2,3-thiodiazole compound and amine under the catalysis of copper. The method comprises the following steps: in a protective atmosphere, taking an organic solvent as a reaction medium, reacting a 1,2,3-thiodiazole compound with an amine compound under the action of a copper salt catalyst or a copper catalyst and a phosphine ligand, and carrying out subsequent treatment to obtain the thioamide compound. According to the method, the copper salt is used as the catalyst, the phosphine ligand is adopted, the yield is high, and the substrate applicability is wide. In addition, the reaction takes the 1,2,3-thiodiazole compound and the amine compound as raw materials, and has the advantages that the raw materials are cheap and easy to prepare, the operation is simple and convenient, and the atom economy is high.
O,O-Diethyl dithiophosphoric acid mediated direct synthesis of thioamides from aldehydes and ketones
Yadav, Arvind K.,Srivastava, Vishnu P.,Yadav, Lal Dhar S.
, p. 7113 - 7116 (2013/01/15)
A general and convenient method for a one-pot conversion of aldehydes and ketones into thioamides has been developed. The protocol involves oximation of aldehydes and ketones followed by deoxygenative thioamidation of oximes with O,O-diethyl dithiophosphoric acid which acts as an acid as well a source of sulfur. The method is operationally simple, high yielding, and also applicable to the conversion of amides and nitriles into the corresponding thioamides.
Facile and odorless one-pot process for the synthesis of N-substituted thioamides via TsCl-mediated Beckmann rearrangement of ketoximes
Liu, Li-Feng,An, Na,Pi, Hong-Jun,Ying, Jun,Du, Wenting,Deng, Wei-Ping
supporting information; experimental part, p. 979 - 981 (2011/06/11)
A facile and odorless one-pot thionation process for the synthesis of N-substituted thioamides using chemically stable and inexpensive thiourea reagent via the Beckmann rearrangement of ketoximes, has been described. Georg Thieme Verlag Stuttgart · New York.
Ketoximes to N-substituted thioamides via PSCl3 mediated Beckmann rearrangement
Pathak, Uma,Pandey, Lokesh Kumar,Mathur, Sweta,Suryanarayana
scheme or table, p. 5409 - 5411 (2009/12/08)
N-Substituted thioamides were accessed from ketoximes by utilising PSCl3 as a uniquely capable reagent to induce Beckmann rearrangement as well as to capture the intermediate nitrilium ion. The Royal Society of Chemistry 2009.
Kinetics and mechanism of the aminolysis of aryl phenyldithioacetates in acetonitrile
Oh, Hyuck Keun,Kim, Sun Kyung,Cho, In Ho,Lee, Hai Whang,Lee, Ikchoon
, p. 2306 - 2310 (2007/10/03)
The aminolysis reactions of Z-aryl phenyldithioacetates (C6H5CH2C(=S)SC6H4Z) with benzylamines (XC6H4CH2NH2) are investigated in acetonitrile at -25.0 °C. T
