127138-50-5Relevant academic research and scientific papers
Synthesis of ertugliflozin from D-glucose
Triantakonstanti, Virginia V.,Andreou, Thanos,Koftis, Theoharis V.,Gallos, John K.
, p. 994 - 996 (2019)
A new synthesis of ertugliflozin from D-glucose in 7% overall yield is reported. The reaction sequence involves conversion of D-glucose to a fully protected open chain D-glucose aldehyde in 4 steps, further installation of the aglycon group by a Grignard
A NOVEL PROCESS FOR THE PREPARATION OF SGLT-2 INHIBITORS
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Page/Page column 16; 17, (2020/01/24)
The present invention relates to a novel process for the preparation of SGLT-2 inhibitors via addition of a hydroxymethylene group in an open chain intermediate, readily accessible from D-glucose.
