60405-34-7

Upstream product

• 60405-33-6 6-O-benzoyl-D-glucose diethyl dithiacetal 
• 77-76-9 2,2-dimethoxy-propane 
• 67-64-1 acetone 
• 98-88-4 benzoyl chloride 
• 1941-52-2 D-glucose diethyl mercaptal 

Downstream Products

• 127138-50-5 Benzoic acid (4R,5R,4'S,5'R)-5'-formyl-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-ylmethyl ester 
• 1210344-57-2 Ertugliflozin 
• 1379587-25-3 ethyl 1-thio-α-D-glucoseptanoside 
• 7473-36-1 (2R,3R,4S,5S,6R)-2-Ethylsulfanyl-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol 
• 1379587-26-4 ethyl 1-thio-2,3,4,5-tetra-O-acetyl-α-D-glucoseptanoside 
• 32934-24-0 ethyl 2,3,4,6-tetra-O-acetyl-1-thio-α-D-glycopyranoside 
• 39697-82-0 ethyl 1-thio-α-D-glucofuranoside tetraacetate 
• 73982-71-5 (2R)-2-deoxy-2-deuterio-D-arabino-hexose 
• 154-17-6 D-2-deoxyglucose 

Relevant academic research and scientific papers

A NOVEL PROCESS FOR THE PREPARATION OF SGLT-2 INHIBITORS

The present invention relates to a novel process for the preparation of SGLT-2 inhibitors via addition of a hydroxymethylene group in an open chain intermediate, readily accessible from D-glucose.

Synthesis of ertugliflozin from D-glucose

A new synthesis of ertugliflozin from D-glucose in 7% overall yield is reported. The reaction sequence involves conversion of D-glucose to a fully protected open chain D-glucose aldehyde in 4 steps, further installation of the aglycon group by a Grignard