127199-14-8

Basic information

• Product Name: (1S,2S)-2-Fluorocyclopropanecarboxylic acid
• Synonyms: Cyclopropanecarboxylic acid, 2-fluoro-, (1S,2S)-;(1S,2S)-2-FLUOROCYCLOPROPANECARBOXYLIC ACID(WX900028);(cis)-2-fluorocyclopropanecarboxylic acid Relative stereochemistry
• CAS NO: 127199-14-8
• Molecular Formula: C₄H₅FO₂
• Molecular Weight: 104.0797032
• Product Categories: organic building block
• Mol File: 127199-14-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 202.3±33.0 °C(Predicted)
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.78±0.20(Predicted)
• CAS DataBase Reference: (1S,2S)-2-Fluorocyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-2-Fluorocyclopropanecarboxylic acid(127199-14-8)
• EPA Substance Registry System: (1S,2S)-2-Fluorocyclopropanecarboxylic acid(127199-14-8)

Safety Data

• Hazardous Substances Data: 127199-14-8(Hazardous Substances Data)

Usage

General Description

(1S,2S)-2-Fluorocyclopropanecarboxylic acid is a chemical compound with the molecular formula C4H5FO2. It is a cyclopropane derivative with a carboxylic acid functional group and a fluorine substituent. (1S,2S)-2-Fluorocyclopropanecarboxylic acid is a chiral molecule, with two stereocenters at the 1 and 2 positions, giving rise to the (1S,2S) configuration. It is used in organic synthesis and pharmaceutical research as a building block for the preparation of various biologically active compounds. The unique structure of (1S,2S)-2-Fluorocyclopropanecarboxylic acid makes it a valuable tool in medicinal chemistry for the development of new drugs and pharmaceuticals.

Upstream product

• 154001-42-0 C₄H₅FO₂*C₁₅H₁₇N 
• 216872-00-3 (1R,2R)-2-Fluoro-cyclopropanecarboxylic acid propyl ester 
• 216872-25-2 (1S,2S)-2-Fluoro-cyclopropanecarboxylic acid hexyl ester 
• 177564-60-2 (1S,2S)-2-Fluoro-cyclopropanecarboxylic acid pentyl ester 
• 161582-46-3 (1R,2R)-2-Fluoro-cyclopropanecarboxylic acid butyl ester 
• 161582-46-3 (1S,2S)-2-Fluoro-cyclopropanecarboxylic acid butyl ester 
• 177564-59-9 (1S,2S)-2-Fluoro-cyclopropanecarboxylic acid propyl ester 
• 177933-51-6 (1S,2S)-2-Fluorocyclopropanecarboxylic Acid Ethyl Ester 
• 188428-48-0 cis-ethyl 2-fluorocyclopropanecarboxylate 
• 127199-12-6 (1S,2S)-2-Fluoro-cyclopropanecarboxylic acid ((R)-1-phenyl-ethyl)-amide 
• 152237-14-4 tert-butyl 2-fluoro-cyclopropane-1-carboxylate 
• 137081-42-6 2-chloro-2-fluorocyclopropane carboxylic acid 

Downstream Products

• 185225-82-5 (±)-trans-2-fluorocyclopropanecarbonyl chloride 
• 185225-82-5 (1R,2S)-2-fluorocyclopropane carbonyl chloride 

Relevant articles and documents

Novel process for synthesizing 2 -fluorocyclopropylamine with high selectivity and asymmetric synthesis

A novel highly selective asymmetric synthesis process of 2 -fluorocyclopropylamine (Structural I). The method provided by the invention uses 1 - fluorine -1 - benzene (propylene) sulfonyl methane and chiral epichlorohydrin to construct chiral cyclopropane under basic conditions, and a new synthetic route not only achieves a special cis-trans selectivity, but also has a highly specific stereoselectivity. The synthesis route is efficient, the reaction condition is mild, the method is suitable for large industrial production in a green environment, 2 -fluorocyclopropylamine production cost is greatly reduced.

Stereoselective synthesis of cis -2-fluorocyclopropanecarboxylic acid

A rhodium-catalyzed cyclopropanation of 1-fluoro-1-(phenylsulfonyl)ethylene and diazo esters is described as an effective method for the stereoselective synthesis of cis-2-fluorocyclopropanecarboxylic acid. This process provides an example of the cyclopro

PROCESS FOR REDUCTIVE DEHALOGENATION

A method ofproducing2-fluorocyclopropane-1-carboxylic acid ester, which comprise by allowing a compound represented by the following formula (1): wherein X represents a chlorine atom, a bromine atom or an iodine atom; and R1 represents an alkyl