185225-82-5

Basic information

• Product Name: (1S-TRANS)-2-FLUOROCYCLOPROPANECARBONYL CHLORIDE
• Synonyms: (1S-TRANS)-2-FLUOROCYCLOPROPANECARBONYL CHLORIDE
• CAS NO: 185225-82-5
• Molecular Formula: C4H4ClFO
• Molecular Weight: 122.53
• Mol File: 185225-82-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1S-TRANS)-2-FLUOROCYCLOPROPANECARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (1S-TRANS)-2-FLUOROCYCLOPROPANECARBONYL CHLORIDE(185225-82-5)
• EPA Substance Registry System: (1S-TRANS)-2-FLUOROCYCLOPROPANECARBONYL CHLORIDE(185225-82-5)

Safety Data

• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• Hazardous Substances Data: 185225-82-5(Hazardous Substances Data)

Usage

General Description

(1S-TRANS)-2-Fluorocyclopropanecarbonyl chloride is a chemical compound with the molecular formula C4H5ClF. It is a colorless to pale yellow liquid that is used in the synthesis of various pharmaceuticals and agrochemicals. (1S-TRANS)-2-FLUOROCYCLOPROPANECARBONYL CHLORIDE is a valuable building block in organic chemistry, as the cyclopropane ring provides a rigid and compact structure that can be manipulated to introduce specific functional groups. The carbonyl chloride group also allows for the attachment of other chemical moieties, making this compound useful in the development of new drugs and crop protection products. Additionally, the fluorine atom adds unique properties to the molecule, such as increased lipophilicity and metabolic stability, which can improve its effectiveness in biological systems. Overall, (1S-TRANS)-2-Fluorocyclopropanecarbonyl chloride is a versatile and important chemical intermediate in the production of a wide range of valuable compounds.

Upstream product

• 127199-13-7 (1R,2R)-(-)-cis-2-fluoro-cyclopropanecarboxylic acid 
• 105919-34-4 (+/-)-trans-2-fluorocyclopropanecarboxylic acid 
• 127199-14-8 (1S,2S)-2-fluorocyclopropane-1-carboxylic acid 
• 167073-07-6 (±)-cis-2-fluorocyclopropanecarboxylic acid 

Relevant articles and documents

JAK kinase inhibitor and application thereof

The invention discloses a JAK kinase inhibitor and an application thereof. The JAK kinase inhibitor is a compound represented by a formula I or a stereoisomer, a tautomer or pharmaceutically acceptable salt or a solvate or a prodrug of the compound; the invention further provides the application of the compound represented by the formula I in preparation of drugs for preventing or treating JAK kinase related diseases, and in particular, relates to the application in preparing medicines for preventing and/or treating diseases related to cartilage degeneration and bone and/or joint degeneration,diseases related to inflammation or immune response, endotoxin-driven disease states, cancers and organ transplantation rejection.

INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE

Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

5-PHENYLAZAINDOLE DERIVATIVE HAVING AMPK ACTIVATING EFFECT

Provided is a compound which is useful as an AMPK activator. A compound represented by formula: wherein X is substituted or unsubstituted monocyclic heterocyclyl or the like; ring A is substituted aryl, substituted heteroaryl, substituted cycloalkyl, substituted cycloalkenyl, or substituted heterocyclyl, wherein the ring A may further have a substituent(s) other than Y; Y is halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like; R4, R5, R6 and R7 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted acyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted sulfamoyl, or substituted or unsubstituted amino; R8 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like; and R9 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like, or its pharmaceutically acceptable salt.