127285-08-9

Basic information

• Product Name: 1-ISOPROPYL-PIPERIDIN-4-YLAMINE
• Synonyms: 4-Piperidinamine, 1-(1-methylethyl)-;1-isopropylpiperidin-4-amine(SALTDATA: 1.98HCl 0.34H2O);1-isopropylpiperidin-4-amine 1.98HCl 0.34H2O;1-(propan-2-yl)piperidin-4-aMine;1-(Prop-2-yl)piperidin-4-amine, 1-Isopropylpiperidin-4-amine;1-Isopropyl-4-PiperidinaMine;(1-isopropyl-4-piperidyl)amine;1-ISOPROPYLPIPERIDIN-4-AMINE
• CAS NO: 127285-08-9
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142.24
• Product Categories: Heterocycles
• Mol File: 127285-08-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 173.2 °C at 760 mmHg
• Flash Point: 58.9 °C
• Appearance: /
• Density: 0.904 g/cm³
• Vapor Pressure: 1.28mmHg at 25°C
• Refractive Index: 1.4720 to 1.4760
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.51±0.20(Predicted)
• CAS DataBase Reference: 1-ISOPROPYL-PIPERIDIN-4-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ISOPROPYL-PIPERIDIN-4-YLAMINE(127285-08-9)
• EPA Substance Registry System: 1-ISOPROPYL-PIPERIDIN-4-YLAMINE(127285-08-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39
• RIDADR: UN 2920 8/3/PG II
• HazardClass: IRRITANT
• PackingGroup: II
• Hazardous Substances Data: 127285-08-9(Hazardous Substances Data)

Usage

General Description

1-Isopropyl-piperidin-4-ylamine is a chemical compound with a molecular formula C10H22N2. It is used as a building block in the synthesis of pharmaceutical compounds and agrochemicals. 1-ISOPROPYL-PIPERIDIN-4-YLAMINE is a substituted amine with a piperidine ring that contains an isopropyl group. Its primary use is as an intermediate in the production of antihistamines, analgesics, and other pharmaceuticals. It is also used as a corrosion inhibitor, a polymerization inhibitor, and in the synthesis of specialty chemicals. The compound is flammable and should be handled with proper care and precautions.

InChI:InChI=1/C8H18N2/c1-7(2)10-5-3-8(9)4-6-10/h7-8H,3-6,9H2,1-2H3

Upstream product

• 534595-37-4 (1-isopropylpiperidin-4-yl)carbamic acid tert-butyl ester 
• 182223-54-7 piperidin-4-ylcarbamic acid benzyl ester 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 220394-97-8 4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)piperidine 
• 609804-23-1 benzyl (1-iso-propylpiperidin-4-yl)carbamate 
• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 

Downstream Products

• 534573-39-2 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide 
• 959242-49-0 N-(1-isopropylpiperidin-4-yl)-2-phenylacetamide 

Relevant articles and documents

Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in?vivo anti-tumor activity

Novel 1H-benzo[d]immidazole-4-carboxamide derivatives bearing five-membered or six-membered N-heterocyclic moieties at the 2-position were designed and synthesized as PARP-1 inhibitors. Structure-activity relationships were conducted and led to a number of potent PARP-1 inhibitors having IC50 values in the single or double digit nanomolar level. Some potent PARP-1 inhibitors also had similar inhibitory activities against PARP-2. Among all the synthesized compounds, compound 10a and 11e displayed strong potentiation effects on temozolomide (TMZ) in MX-1?cells (PF50?=?7.10, PF50?=?4.17). In?vivo tumor growth inhibition was investigated using compound 10a in combination with TMZ, and it was demonstrated that compound 10a could strongly potentiate the cytotoxicity of TMZ in MX-1 xenograft tumor model. Two co-crystal structures of compounds 11b and 15e complexed with PARP-1 were achieved and demonstrated a unique binding mode of these benzo-imidazole derivatives.

TROPANE COMPOUNDS

A compound according to Formula I or II: (I) or (II) wherein R1, R1b, R2, L1, and L2 and L2b are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.

ALKYLCARBAMOYL NAPHTHALENYLOXY- OCTENOYLHYDROXYAMIDE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PREPARATION THEREOF

This invention discloses a novel alkylcarbamoyl naphthalenyloxy octenoylhydroxyamide derivative of formula (1) useful for inhibiting the enzyme activity of histone deacetylase, which leads to effective suppression of the cancer cell proliferation, a method for preparing same and a pharmaceutical composition comprising same.