127300-01-0

Basic information

• Product Name: 1-propyl-4-(3,3,3-trifluoroprop-1-yn-1-yl)benzene
• Synonyms: 1-propyl-4-(3,3,3-trifluoroprop-1-yn-1-yl)benzene
• CAS NO: 127300-01-0
• Molecular Weight: 212.215
• Mol File: 127300-01-0.mol

Chemical Properties

• CAS DataBase Reference: 1-propyl-4-(3,3,3-trifluoroprop-1-yn-1-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-propyl-4-(3,3,3-trifluoroprop-1-yn-1-yl)benzene(127300-01-0)
• EPA Substance Registry System: 1-propyl-4-(3,3,3-trifluoroprop-1-yn-1-yl)benzene(127300-01-0)

Safety Data

• Hazardous Substances Data: 127300-01-0(Hazardous Substances Data)

Upstream product

• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 62452-73-7 1-ethynyl-4-propylbenzene 
• 887144-97-0 Togni's reagent 
• 1415023-66-3 C₁₁H₁₁BF₃^(1-)*K⁽¹⁺⁾ 
• 147531-11-1 trifluoromethanesulfonic acid diphenyl(trifluoromethyl)sulfonium salt 
• 2926-29-6 Langlois reagent 

Relevant articles and documents

Copper-mediated trifluoromethylation of potassium alkynyltrifluoroborates with Langlois' reagent Dedicated to Professor Pierre Vogel on the occasion of his 70th birthday

Synthesis of trifluoromethylated acetylenes by copper-mediated trifluoromethylation of potassium alkynyltrifluoroborates with CF3 radicals generated from NaSO2CF3 and tert-butyl hydroperoxide (TBHP) is communicated. The trifluoromethylated acetylenes were obtained in good to moderate yields. The presented method tolerates a wide range of aromatic, heteroaromatic, and aliphatic potassium alkynyltrifluoroborates.

Copper-mediated trifluoromethylation of terminal alkynes by S-(trifluoromethyl)diarylsulfonium salt

The copper-mediated trifluoromethylation of terminal alkynes with S-(trifluoromethyl)diarylsulfonium salt has been carefully investigated. The reactions proceeded smoothly to afford trifluoromethylated acetylenes in moderate to good yields. This approach is a convenient method to synthesize a variety of functional trifluoromethylated acetylenes. A convenient method for the trifluoromethylation of a variety of terminal alkynes with S-(trifluoromethyl)diarylsulfoniumtriflate in the presence of copper iodide was described. The reactions proceeded smoothly under mild condition to give the desired product in moderate to good yields. Copyright

Synthesis of trifluoromethylated acetylenes via copper-catalyzed trifluoromethylation of alkynyltrifluoroborates

A new method for the synthesis of trifluoromethylated acetylenes is developed which involves the copper-catalyzed trifluoromethylation of alkynyltrifluoroborates with an electrophilic trifluoromethylating reagent. This method offers significant advantages such as efficiency and mild and base-free reaction conditions. A plausible mechanism is proposed.

Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent

A catalytic process for trifluoromethylation of terminal alkynes with Togni's reagent has been developed, affording trifluoromethylated acetylenes in good to excellent yields. The reaction is conducted at room temperature and exhibits tolerance to a range

Copper-mediated aerobic oxidative trifluoromethylation of terminal alkynes with Me3SiCF3

An efficient copper-mediated trifluoromethylation of terminal alkynes with nucleophilic trifluoromethylating reagent (Me3SiCF3) was developed. Both aromatic alkynes and aliphatic alkynes were effective, and a variety of functionalities such as amino, -OMe, -CO2Et, -Br, and -NO2 were tolerated under the reaction conditions. This reaction provides a general, straightforward, and practically useful method to prepare trifluoromethylated acetylenes.