1273551-93-1Relevant articles and documents
Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors
Alvala, Mallika,Angeli, Andrea,Argulwar, Omkar S.,Arifuddin, Mohammed,Soman, Jyothsna,Sridhar Goud, Nerella,Supuran, Claudiu T.,Thacker, Pavitra S.
, (2020/10/02)
Two series, coumarin-linked to thiazolidinone via a pyrazole linker (6a-m, Series 1) and coumarin-linked 1,2,3-triazoles (5a-j, Series 2) were synthesized and the synthesized compounds were subjected for evaluation against the four physiologically and pha
Synthesis of novel substituted 3-(4-((1H-benzo[d]imidazol-2-ylthio)methyl)-1-phenyl-1H-pyrazol-3-yl)-2H-chromen-2-ones: various approaches
Srikrishna, Devulapally,Dubey, Pramod Kumar
, p. 4455 - 4468 (2018/03/29)
Abstract: Considering benzimidazole as a privileged structure for developing probes of impressive pharmacological potentials, some new coumarin and pyrazole conjugates of benzimidazoles were synthesized with a sulphur linkage. Thus, 3-(2-oxo-2H-chromen-3-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde (3) was prepared starting from simple salicylaldehyde which has been?used as an important synthon and incorporated in a series of structural manipulations to obtain various of pharmacophoric motif conjugates 9(a–b) and 13(a–f), in fair yields. We have developed facile and stepwise methods for the synthesis of all these compounds in various approaches, which also involves sub-sequences. All synthesized compounds were well characterized by IR, 1HNMR, 13CNMR and mass spectra data.
Instantaneous and Selective Bare Eye Detection of Inorganic Fluoride Ion by Coumarin–Pyrazole-Based Receptors
Jain, Anshu,Gupta, Ragini,Agarwal, Madhu
, p. 2808 - 2816 (2017/09/26)
A series of rationally designed coumarin–pyrazole-based scaffolds, equipped with N―H and C―H hydrogen bond donors (R1–R5) and containing various electron-withdrawing groups at key positions, are synthesized and characterized in order to investigate their
