127369-30-6

Basic information

• Product Name: L-P-HYDROXYPHENYLGLYCINE METHYL EST
• Synonyms: L-P-HYDROXYPHENYLGLYCINE METHYL EST;Methyl (2S)-amino(4-hydroxyphenyl)ethanoate hydrochloride;(S)-Methyl 2-amino-2-(4-hydroxyphenyl)acetate HCl;S-4-Hydroxyphenylglycine methyl ester hydrochloride
• CAS NO: 127369-30-6
• Molecular Formula: C₉H₁₁NO₃*ClH
• Molecular Weight: 217.64948
• Mol File: 127369-30-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 179-183 °C(lit.)
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: L-P-HYDROXYPHENYLGLYCINE METHYL EST(CAS DataBase Reference)
• NIST Chemistry Reference: L-P-HYDROXYPHENYLGLYCINE METHYL EST(127369-30-6)
• EPA Substance Registry System: L-P-HYDROXYPHENYLGLYCINE METHYL EST(127369-30-6)

Safety Data

• Hazardous Substances Data: 127369-30-6(Hazardous Substances Data)

Usage

Uses

Methyl (2S)-2-amino-2-(4-hydroxyphenyl)acetate Hydrochloride acts as a reagent in the synthesis of Amoxicillin, an antibiotic for the treatment of bacterial infection.

Upstream product

• 67-56-1 methanol 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 37763-23-8 D-2-p-hydroxyphenylglycine methyl ester 

Downstream Products

• 115142-79-5 N-(2-methylcinnamylidene)-α-p-hydroxyphenylglycine methyl ester 
• 143323-49-3 (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate 
• 1195785-28-4 C₂₄H₂₈FN₃O₈ 
• 1352241-33-8 C₁₃H₁₅NO₆ 
• 1352241-31-6 methyl 4-hydroxy-5-(4-hydroxyphenyl)-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate 
• 1352241-34-9 5-(4-hydroxyphenyl)pyrrolidine-2,4-dione 
• 1352241-32-7 (4Z)-4-hydrazinylidene-5-(4-hydroxyphenyl)pyrrolidin-2-one 
• 1315334-91-8 C₃₅H₂₉NO₅ 
• 1315334-92-9 C₃₅H₂₉NO₅ 
• 1315334-95-2 C₄₁H₄₅NO₅Si₂ 
• 1315334-96-3 C₄₁H₄₅NO₅Si₂ 
• 1315334-93-0 C₃₁H₂₇Br₂NO₅ 
• 1315334-94-1 C₃₁H₂₇Br₂NO₅ 
• 113850-72-9 (R)-N-tert-butoxycarbonyl-3',5'-diiodo-4'-methoxyphenylglycine methyl ester 

Relevant articles and documents

Preparation method of (-) - Cytoxazone and (+) -4 - epi-Cytoxazone

The preparation method of (-) - Cytoxazone and (+) -4 - epi-Cytoxazone takes D - p-hydroxyphenylglycine as a raw material, the intermediate 2 is obtained through methyl esterification reaction under catalysis of thionyl chloride, and then the amino is protected with Boc anhydride to obtain the intermediate 3. The compound 4 is obtained by using potassium carbonate as a base and reacting with methyl iodide under reflux conditions. The methyl ester was reduced with sodium borohydride/lithium chloride to give the primary alcohol compound 5. An intermediate IBX is then obtained with 6 primary alcohol, then reacted with acetone cyanohydrin SN2 to give intermediate 7, and the intermediate 8 is obtained by reacting with the methanol solution of hydrogen chloride to obtain two five-membered ring compound compounds 9 and 10, respectively, with sodium borohydride to obtain (-) - Cytoxazone and its isomers (+) -4 - epi-Cytoxtoxtoxtoxol, respectively.

Intermediate of RORgamma inhibitor and preparation method thereof

The invention belongs to the technical field of drugs, in particular to an intermediate of a RORgamma inhibitor and a preparation method thereof. The intermediate is as shown in a formula (I). The method has the advantages of being easily available in raw material, concise in process, economic and environment-friendly, high in yield and the like. The formula is as shown in the description.

NOVEL ANTIESTROGENIC HETEROCYCLIC COMPOUNDS

The present invention provides novel heterocyclic compounds of Formula I wherein A, B, E, ring Z, Y, L, ring X, D, m, n, R7 and R8 are as defined in the specification as estrogen receptor antagonists/degraders. The compound of Formula I can be used for the treatment of cancers mediated by estrogen receptors. (Formula I ).