127441-50-3

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 111-46-6 diethylene glycol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 628-89-7 2-(2-Chloroethoxy)ethanol 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 444727-38-2 2-(2-{4-[(E)-2-(4-{(E)-2-[4-(2-Ethyl-hexane-1-sulfonyl)-phenyl]-vinyl}-phenyl)-vinyl]-phenoxy}-ethoxy)-ethanol 
• 444727-37-1 1-<4-<2-(2-hydroxyethoxy)ethoxy>styryl>-4-(4-decylsulfonylstyryl)benzene 
• 1285534-51-1 (1E,4E)-1-(4-(dimethylamino)phenyl)-5-(4-(2-(2-hydroxyethoxy)ethoxy)phenyl)penta-1,4-dien-3-one 
• 1287199-72-7 C₁₉H₂₀O₆ 

Relevant academic research and scientific papers

BINUCLEAR PALLADACYCLES AND THEIR USE IN THE TREATMENT OF CANCER

This invention relates to a series of binuclear palladacycle compounds, and methods for the production of these compounds, that are suitable for use in the treatment of cancer.

Selective Single-Step Oxidation of Amine to Cross-Azo Compounds with an Unhampered Primary Benzyl Alcohol Functionality

This is the first report of a single-step synthesis of primary benzyl alcohol containing different cross-azo compounds (14 examples) by Cu(II) in the presence of a newly synthesized amino-ether heteroditopic macrobicycle cage. Interestingly, even with ext

Photo/nickel synergistic catalysis method for monoarylation of diol

The invention discloses a photo/nickel synergistic catalysis method for monoarylation of a diol. The method directly uses a brominated aromatic hydrocarbon and a diol as raw materials, wherein the brominated aromatic hydrocarbon and the diol are simple and easy to obtain, and adopts a BODIPY organic photosensitizer and an inexpensive nickel source to synergistically catalyze cross-coupling of thediol and the brominated aromatic hydrocarbon without an additionally-added ligand to realize selective monoarylation of a diol compound, and a mono/dual arylation ratio is up to 18:1. The method disclosed by the invention has good tolerance of functional groups and is suitable for a plurality of diol compounds with different structures, such as o-diol, 1,3-diol, 1,4-diol and monodisperse polyethylene glycol; more importantly, the photosensitizer used in the method has a low using amount, the reaction temperature is close to room temperature, and the method is green, economical and highly-efficient; and the advantages make the method have higher scale synthetic value and can serve social and economic development.

Radiolabeled pyridinyl analogues of dibenzylideneacetone as β-amyloid imaging probes

In continuation of our investigation of the dibenzylideneacetone scaffold as Aβ imaging probes, a series of derivatives containing pyridine rings with lower lipophilicity was synthesized and evaluated. Some of these probes displayed high affinities to Aβ

Synthesis and investigation of novel benzimidazole derivatives as antifungal agents

The rise and emergence of resistance to antifungal drugs by diverse pathogenic fungal strains have resulted in an increase in demand for new antifungal agents. Various heterocyclic scaffolds with different mechanisms of action against fungi have been investigated in the past. Herein, we report the synthesis and antifungal activities of 18 alkylated mono-, bis-, and trisbenzimidazole derivatives, their toxicities against mammalian cells, as well as their ability to induce reactive oxygen species (ROS) in yeast cells. Many of our bisbenzimidazole compounds exhibited moderate to excellent antifungal activities against all tested fungal strains, with MIC values ranging from 15.6 to 0.975?μg/mL. The fungal activity profiles of our bisbenzimidazoles were found to be dependent on alkyl chain length. Our most potent compounds were found to display equal or superior antifungal activity when compared to the currently used agents amphotericin B, fluconazole, itraconazole, posaconazole, and voriconazole against many of the strains tested.

NOVEL BENZYLIDENE AZOLIDINE DERIVATIVE OR SALT THEREOF

Provided is a novel compound which has excellent ultraviolet-absorbing function (especially UVA absorbing function) and excellent hydrophilicity. A benzylidene azolidine derivative of the present invention or a salt thereof is characterized by being a ben

Self-assembly of indolocarbazole-containing macrocyclic molecules

A successful approach for the synthesis of indolocarbazole-containing macrocycles based upon π-π stacking preorganization of indolocarbazole planes and click-chemistry reactions has been developed. The macrocycles are able to form folded structures with t

Construction of an interpenetrated structure of macrocycles

The construction of an interpenetrated structure of macrocycles by a CuAAC click reaction was achieved and the binding selectivity of indolocarbazole for a chloride anion was enhanced upon catenanation.

Synthesis and conformational analysis of macrocyclic dihydroxystilbenes linked between the para-para positions

A new family of diphenylethanes has been synthesized as conformationally restricted analogues of antimitotic combretastatins. The two phenyl rings are linked between the para-phenolic positions through a 3-oxapentamethylene or hexamethylene chain. The key

Synthesis and optical characterization of unsymmetrical oligophenylenevinylenes

An efficient route to highly soluble unsymmetrical oligo(phenylenevinylenes) (OPVs) has been developed. The OPVs are end-substituted with donor alkoxy and acceptor sulfonyl groups for charge polarization and incorporate a methacrylate unit suitable for co-polymerization. The absorption and excitation spectra of the OPVs and their precursors have been examined; vibronic features are noted, and π-system lengthening and introduction of polarizing substituents red-shift the spectral maxima.