127451-46-1

Upstream product

• 55613-61-1 (Z)-4-chlorobut-2-en-1-yl acetate 
• 55022-46-3 4-methyl-N-prop-2-ynylbenzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 26924-02-7 (Z)-4-bromo-2-butenyl acetate 

Downstream Products

• 127451-52-9 4-Methylene-2-(toluene-4-sulfonyl)-2,3,3a,4-tetrahydro-1H-cyclopenta[c]pyrrol-5-one 
• 121224-85-9 [(S)-1-(Toluene-4-sulfonyl)-4-vinyl-pyrrolidin-(3E)-ylidene]-acetic acid methyl ester 
• 127451-49-4 [5-Oxo-2-(toluene-4-sulfonyl)-1,2,3,3a,4,5-hexahydro-cyclopenta[c]pyrrol-4-yl]-acetic acid methyl ester 
• 1334209-45-8 (E)-6-(N-(prop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate 
• 1334209-47-0 (E)-6-(N-(3-phenylprop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate 
• 1365555-72-1 C₂₂H₂₁NO₃S 
• 1365555-08-3 (E)-ethyl 7-(N-(prop-2-ynyl)-N-tosylamino)-4-(pivaloyloxy)hept-5-en-2-ynoate 
• 1365555-10-7 (E)-1-(N-(prop-2-ynyl)-N-tosylamino)-7-oxooct-2-en-5-yn-4-yl pivalate 
• 1365555-11-8 (E)-1-(N-(prop-2-ynyl)-N-tosylamino)-7-oxododec-2-en-5-yn-4-yl pivalate 
• 1365555-62-9 C₁₉H₂₁NO₅S 
• 1365555-13-0 (E)-7-(N-(prop-2-ynyl)-N-tosylamino)-1-oxo-1-phenylhept-5-en-2-yn-4-yl pivalate 
• 1365555-64-1 C₂₉H₄₃NO₅SSi 

Relevant academic research and scientific papers

Rhodium-catalyzed intra- and intermolecular [5 + 2] cycloaddition of 3-acyloxy-1,4-enyne and alkyne with concomitant 1,2-acyloxy migration

A new type of rhodium-catalyzed [5 + 2] cycloaddition was developed for the synthesis of seven-membered rings with diverse functionalities. The ring formation was accompanied by a 1,2-acyloxy migration event. The five- and two-carbon components of the cycloaddition are 3-acyloxy-1,4-enynes (ACEs) and alkynes, respectively. Cationic rhodium(I) catalysts worked most efficiently for the intramolecular cycloaddition, while only neutral rhodium(I) complexes could facilitate the intermolecular reaction. In both cases, electron-poor phosphite or phosphine ligands often improved the efficiency of the cycloadditions. The scope of ACEs and alkynes was investigated in both the intra- and intermolecular reactions. The resulting seven-membered-ring products have three double bonds that could be selectively functionalized.

Palladium-Catalyzed 'Metallo-Ene'-Type Cyclization/Vinylstannane Coupling of 1-Acetoxy-octa-2,7-dienes and 1-Acetoxy-oct-2-en-7-ynes

Palladiumbis(dibenzylideneacetone)/tri(2-furyl)phosphine-catalyzed cyclizations of dienyl acetates 2 in the presence of an (1-alkenyl)(tributyl)stannane and ZnCl2 provided trans-substituted 3-alkenyl-4-vinylcyclopentanes 11 in good yields.Analogous intram