1334209-45-8

Basic information

• Product Name: (E)-6-(N-(prop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate
• Synonyms: (E)-6-(N-(prop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate
• CAS NO: 1334209-45-8
• Molecular Weight: 387.5
• Mol File: 1334209-45-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-6-(N-(prop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-6-(N-(prop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate(1334209-45-8)
• EPA Substance Registry System: (E)-6-(N-(prop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate(1334209-45-8)

Safety Data

• Hazardous Substances Data: 1334209-45-8(Hazardous Substances Data)

Upstream product

• 774242-01-2 N-[(2Z)-4-hydroxybut-2-en-1-yl]-4-methyl-N-prop-2-yn-1-ylbenzenesulfonamide 
• 384836-87-7 (2E)-N-(3-formyl-2-propenyl)-N-(2-propynyl)tosylamide 
• 127451-46-1 N-(4-acetoxybut-2-enyl)-N-(prop-2-ynyl)-p-toluenesulfonamide 
• 3282-30-2 pivaloyl chloride 
• 55022-46-3 4-methyl-N-prop-2-ynylbenzenesulfonamide 
• 595582-93-7 C₁₄H₁₇NO₃S 
• 930607-96-8 4-(4-methyl-N-(prop-2-yn-1-yl)phenylsulfonamido)but-2-en-1-yl acetate 

Downstream Products

• 1334209-60-7 1,2,3,3a-tetrahydro-2-tosylcyclohepta[c]pyrrol-6-yl pivalate 

Relevant articles and documents

Rhodium-catalyzed intra- and intermolecular [5 + 2] cycloaddition of 3-acyloxy-1,4-enyne and alkyne with concomitant 1,2-acyloxy migration

A new type of rhodium-catalyzed [5 + 2] cycloaddition was developed for the synthesis of seven-membered rings with diverse functionalities. The ring formation was accompanied by a 1,2-acyloxy migration event. The five- and two-carbon components of the cycloaddition are 3-acyloxy-1,4-enynes (ACEs) and alkynes, respectively. Cationic rhodium(I) catalysts worked most efficiently for the intramolecular cycloaddition, while only neutral rhodium(I) complexes could facilitate the intermolecular reaction. In both cases, electron-poor phosphite or phosphine ligands often improved the efficiency of the cycloadditions. The scope of ACEs and alkynes was investigated in both the intra- and intermolecular reactions. The resulting seven-membered-ring products have three double bonds that could be selectively functionalized.