1274804-15-7

Basic information

• Product Name: N-{7-[1-(4'-chlorobiphenyl-2-ylmethyl)piperidin-4-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-4-((R)-3-morpholino-4-yl-1-phenylsulfanylmethylpropylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide
• Synonyms: N-{7-[1-(4'-chlorobiphenyl-2-ylmethyl)piperidin-4-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-4-((R)-3-morpholino-4-yl-1-phenylsulfanylmethylpropylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide
• CAS NO: 1274804-15-7
• Molecular Weight: 959.578
• Mol File: 1274804-15-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-{7-[1-(4'-chlorobiphenyl-2-ylmethyl)piperidin-4-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-4-((R)-3-morpholino-4-yl-1-phenylsulfanylmethylpropylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{7-[1-(4'-chlorobiphenyl-2-ylmethyl)piperidin-4-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-4-((R)-3-morpholino-4-yl-1-phenylsulfanylmethylpropylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide(1274804-15-7)
• EPA Substance Registry System: N-{7-[1-(4'-chlorobiphenyl-2-ylmethyl)piperidin-4-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-4-((R)-3-morpholino-4-yl-1-phenylsulfanylmethylpropylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide(1274804-15-7)

Safety Data

• Hazardous Substances Data: 1274804-15-7(Hazardous Substances Data)

Upstream product

• 1274804-81-7 4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-trifluoromethanesulfonylbenzenesulfonamide 
• 1274804-62-4 3-[4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonyl-benzenesulfonylamino]-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester 
• 1274805-15-0 4-{3-[4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonyl-benzenesulfonylamino]-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl}-piperidine-1-carboxylic acid tert-butyl ester 
• 1027345-12-5 [4-((R)-3-morpholin-4-yl-1-phenylsulfanyl-methyl-propylamino)-3-trifluoromethanesulfonyl]benzenesulfonamide 
• 723286-80-4 3-bromo-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester 
• 1274805-16-1 4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(7-piperidin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-trifluoromethanesulfonyl-benzenesulfonamide 
• 153850-83-0 4'-chlorobiphenyl-2-carboxaldehyde 
• 1679-18-1 4-Chlorophenylboronic acid 
• 6630-33-7 ortho-bromobenzaldehyde 

Relevant articles and documents

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Overexpression of the antiapoptotic members of the Bcl-2 family of proteins is commonly associated with cancer cell survival and resistance to chemotherapeutics. Here, we describe the structure-based optimization of a series of N-heteroaryl sulfonamides t