127526-64-1

Basic information

• Product Name: (R)-(4-benzyloxyphenyl)(tert-butoxycarbonylamino)acetic acid
• Synonyms: (R)-(4-benzyloxyphenyl)(tert-butoxycarbonylamino)acetic acid
• CAS NO: 127526-64-1
• Molecular Weight: 357.406
• Mol File: 127526-64-1.mol

Chemical Properties

• CAS DataBase Reference: (R)-(4-benzyloxyphenyl)(tert-butoxycarbonylamino)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(4-benzyloxyphenyl)(tert-butoxycarbonylamino)acetic acid(127526-64-1)
• EPA Substance Registry System: (R)-(4-benzyloxyphenyl)(tert-butoxycarbonylamino)acetic acid(127526-64-1)

Safety Data

• Hazardous Substances Data: 127526-64-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-(4-benzyloxyphenyl)(tert-butoxycarbonylamino)acetic acid is used as an intermediate in the synthesis of various pharmaceutical compounds due to its unique structure and functional groups. The Boc group allows for the stepwise construction of peptides, while the benzyl ether group can be strategically placed to protect specific sites during the synthesis process.
Used in Organic Synthesis:
In the field of organic synthesis, (R)-(4-benzyloxyphenyl)(tert-butoxycarbonylamino)acetic acid serves as a versatile building block for the creation of more complex molecules. Its functional groups can be selectively modified or removed to generate a wide range of compounds with different properties and applications.
Used in Research and Development:
(R)-(4-benzyloxyphenyl)(tert-butoxycarbonylamino)acetic acid is also utilized in research and development settings, where it can be employed to study the effects of various functional groups on the properties and reactivity of amino acid derivatives. This knowledge can be applied to the design of new compounds with specific characteristics and potential applications in various industries.
Used in Chemical Education:
As a complex and instructive example of an amino acid derivative, (R)-(4-benzyloxyphenyl)(tert-butoxycarbonylamino)acetic acid can be used in chemical education to illustrate the principles of organic chemistry, peptide synthesis, and the use of protecting groups in the synthesis of complex molecules.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 69489-40-3 D-2-[p-(benzyloxy)phenyl]glycine 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 100-39-0 benzyl bromide 
• 342898-56-0 (R)-(4-benzyloxyphenyl)(tert-butoxycarbonylamino)acetic acid methyl ester 

Downstream Products

• 131080-78-9 N-Boc-4-(benzyloxy)-D-phenylglycine N-succinimido ester 
• 1443793-03-0 N-tert-butyloxycarbonyl-D-[p-(benzyloxy)phenyl]glycine-L-serine-D-[p-(benzyloxy)phenyl]glycine benzyl ester 
• 1443793-02-9 N-tert-butyloxycarbonyl-D-[p-(benzyloxy)phenyl]glycine-L-serine-L-[p-(benzyloxy)phenyl]glycine benzyl ester 
• 1443793-26-7 D-(p-hydroxyphenyl)glycine-L-acetylserine-D-(p-hydroxyphenyl)glycylpantetheine trifluoroacetate 
• 1443793-24-5 D-(p-hydroxyphenyl)glycine-L-acetylserine-L-(p-hydroxyphenyl)glycylpantetheine trifluoroacetate 
• 1443793-21-2 N-(tert-butyloxycarbonyl)-L-acetylserine-L-[p-(benzyloxy)phenyl]glycine benzyl ester 
• 1443793-16-5 N-(tert-butyloxycarbonyl)-D-[p-(benzyloxy)phenyl]glycine-L-tertbutylphosphoserine-D-[p-(benzyloxy)phenyl]glycine benzyl ester 
• 1443793-15-4 N-(tert-butyloxycarbonyl)-D-[p-(benzyloxy)phenyl]glycine-L-tertbutylphosphoserine-L-[p-(benzyloxy)phenyl]glycine benzyl ester 
• 1443793-07-4 D-(p-hydroxyphenyl)glycine-L-serine-D-(p-hydroxyphenyl)glycylpantetheine trifluoroacetate 

Relevant articles and documents

NOVEL ANTIESTROGENIC HETEROCYCLIC COMPOUNDS

The present invention provides novel heterocyclic compounds of Formula I wherein A, B, E, ring Z, Y, L, ring X, D, m, n, R7 and R8 are as defined in the specification as estrogen receptor antagonists/degraders. The compound of Formula I can be used for the treatment of cancers mediated by estrogen receptors. (Formula I ).

Stereocontrolled syntheses of peptide thioesters containing modified seryl residues as probes of antibiotic biosynthesis

Methods have been developed to synthesize tri- and pentapeptide thioesters containing one or more p-(hydroxyphenyl)glycine (pHPG) residues and l-serine, some where the latter is O-phosphorylated, O-acetylated, or exists as a β-lactam. Selection of orthogo

Syntheses of amino alcohols and chiral C2-symmetric bisoxazolines derived from O-alkylated R-4-hydroxyphenylglycine and S-tyrosine

Chiral C2-symmetric bisoxazolines 1b-f and 2b,c, derived from 4′-O-alkylated R-4-hydroxyphenylglycine or S-tyrosine, were prepared. As intermediates, a series of chiral amino alcohols possessing substituted phenolic groups was prepared and fully characterized.

Synthesis and siderophore and antibacterial activity of N5-acetyl-N5-hydroxy-L-ornithine-derived siderophore-β-lactam conjugates: Iron-transport-mediated drug delivery

N5-Acetyl-N5-hydroxy-L-ornithyl-N5-acetyl-N5-hydroxy-L-ornithyl- N5-acetyl-N5-hydroxy-L-ornithine, the functionally instrumental component of the albomycins and ferrichromes, has been incorporated as a ''carrier'' substructure into both carbacephalosporin and oxamazin type β-lactam antibiotics. The previously synthesized protected version of this tripeptide (14) was coupled with various β-lactam analogues 17, 19, 24, and 25 to give protected conjugates 21, 22, 26, and 27. Final deprotection by hydrogenolysis provided the deprotected siderophore-β-lactam antibiotic conjugates 1-4. The growth-promoting ability of each has been evaluated using either the siderophore-deficient mutant Shigella flexneri SA 100 or S. flexneri SA240 (SA 100 iucD:Tn5). Measurement of the growth-promoting activity using two isogenic Escherichia coli strains differing only in the presence or absence of fhuA (hydroxamate ferrichrome receptor) suggests uptake by the hydroxamate iron-transport system. The antibacterial activity of these conjugates has been investigated, and the potential for use of the ferrichrome iron-transport system as a means of drug delivery is discussed.