342898-56-0Relevant academic research and scientific papers
Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as α-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies
Bello, Claudia,Cea, Michele,Bello, Giovanna Dal,Garuti, Anna,Rocco, Ilaria,Cirmena, Gabriella,Moran, Eva,Nahimana, Aimable,Duchosal, Michel A.,Fruscione, Floriana,Pronzato, Paolo,Grossi, Francesco,Patrone, Franco,Ballestrero, Alberto,Dupuis, Marc,Sordat, Bernard,Nencioni, Alessio,Vogel, Pierre
experimental part, p. 3320 - 3334 (2010/07/05)
Novel α-mannosidase inhibitors of the type (2R,3R,4S)-2-({[(1R)-2-hydroxy-1-arylethyl]amino}methyl)pyrrolidine-3,4-diol have been prepared and assayed for their anticancer activities. Compound 30 with the aryl group = 4-trifluoromethylbiphenyl inhibits the proliferation of primary cells and cell lines of different origins, irrespective of Bcl-2 expression levels, inducing a G2/Mcell cycle arrest and by modification of genes involved in cell cycle progression and survival.
Derivatives of Dihydroxypyrrolidine as Anti-Cancer Compounds
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Page/Page column 11; 20, (2009/06/27)
The present invention relates to derivatives of dihydroxypyrrolidine useful in the treatment of cancer. The invention further relates to a process for making the compounds. The compounds are inhibitors of α mannosidase, and possibly, also inhibit nicotina
