127589-93-9

Basic information

• Product Name: 1,1-DIMETHYLETHYL-(R,S)-4-FORMYL-2,2-DIMETHYL-3-OXAZOLIDINECARBOXYLATE
• Synonyms: 1,1-DIMETHYLETHYL-(R,S)-4-FORMYL-2,2-DIMETHYL-3-OXAZOLIDINECARBOXYLATE;1,1-dimethylethyl-(R,S)-4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate, 95 %;tert-Butyl 4-forMyl-2,2-diMethyloxazolidine-3-carboxylate;4-ForMyl-2,2-diMethyl-oxazolidine-3-carboxylic acid tert-butyl ester;4-ForMyl-2,2-DiMethyl-3-Oxazolidinecarboxylic Acid 1,1-DiMethylethyl Ester;tert-butyl 4-formyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate;3-N-Boc-4-Formyl-2,2-dimethyl-oxazolidine;1,1-Dimethylethyl 4-formyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
• CAS NO: 127589-93-9
• Molecular Formula: C₁₁H₁₉NO₄
• Molecular Weight: 229.27
• Mol File: 127589-93-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 1,1-DIMETHYLETHYL-(R,S)-4-FORMYL-2,2-DIMETHYL-3-OXAZOLIDINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-DIMETHYLETHYL-(R,S)-4-FORMYL-2,2-DIMETHYL-3-OXAZOLIDINECARBOXYLATE(127589-93-9)
• EPA Substance Registry System: 1,1-DIMETHYLETHYL-(R,S)-4-FORMYL-2,2-DIMETHYL-3-OXAZOLIDINECARBOXYLATE(127589-93-9)

Safety Data

• Hazardous Substances Data: 127589-93-9(Hazardous Substances Data)

Usage

Uses

4-Formyl-2,2-dimethyl-3-oxazolidinecarboxylic Acid 1,1-Dimethylethyl Ester is a reagent used in the preparation of unsaturated carboxylic esters.

Upstream product

• 108149-63-9 4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester 
• 69942-12-7 N-tert-butoxycarbonylserine methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 157604-46-1 3-tert-butyl 4-methyl 2,2-dimethyl-1,3-oxazolidine-3,4-dicarboxylate 

Downstream Products

• 272772-31-3 (+/-)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-[(4-tolyl)hydroxymethyl]-1,3-oxazolidine 
• 115378-31-9 tert-butyl (4R)-2,2-dimethyl-4-vinyloxazolidine-3-carboxylate 
• 133625-87-3 tert-butyl (4S)-2,2-dimethyl-4-vinyl-1,3-oxazolidine-3-carboxylate 
• 272772-34-6 (+/-)-2-(N-tert-butoxycarbonyl)amino-3-(tert-butyldiphenylsiloxy)-3-(4-methylphenyl)-1-propanal 
• 272772-33-5 (+/-)-2-(N-tert-butoxycarbonyl)amino-3-(tert-butyldiphenylsiloxy)-3-(4-tolyl)-1-propanol 
• 272772-32-4 (+/-)-3-N-tert-butoxycarbonyl-2,2-dimethyl-4-[(4-methylphenyl)(tert-butyldiphenylsiloxy)methyl]-1,3-oxazolidine 

Relevant articles and documents

PYRROLE COMPOUNDS

Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Enantioselective synthesis of Garner's aldehyde by asymmetric hydroformylation

Both enantiomers of Garner's aldehyde (3) are prepared from the same alkene 4 by catalytic asymmetric hydroformylation.

A solid-phase approach to DDB derivatives

Since the discovery of 2,2′-dimethoxycarbonyl-4,4-dimethoxy-5,6, 5′,6′-biomethylenedioxy-biphenyl (DDB) as a potent anti-HBV agent, we have studied the structure-activity relationships of 4,4′-dimethoxy-5, 6,5′,6′-dimethenedioxy-2-alkyloxycarbonyl-2′-(4-substituted benzyl piperazin-1-yl)carbonyl-biphenyl as anti-HBV agents. Therefore, it is rational to extend this study to the 3,3′-disustituted-4,4′- dimethoxy-5,6,5′,6′-dimethenedioxy-2-alkyloxycarbonyl-2′- Serine derivatives. Thus, in an attempt to develop an efficient method for the preparation of a large number of DDB derivatives, the reaction between a DDB acid chloride and serine derivatives on solid support was studied. The structure of resulted compounds was confirmed by LC-MS and 1H NMR analysis. Compounds 2a, 2d, 2f, 2j showed in vitro anti-HBV activity without significant toxicity up to 100 μM.