127605-53-2

Upstream product

• 144787-22-4 t-butyl 2-benzyloxycarbonylamino-3-carboxy-4-phenyl-(2S)-butanoate 
• 100-39-0 benzyl bromide 
• 123975-52-0 t-butyl 2-benzyloxycarbonylamino-3-carbomethoxy-4-phenyl-(2S)-butanoate 
• 60079-12-1 β-Methyl α-tert-butyl (2S)-N-(benzyloxycarbonyl)aspartate 
• 47307-26-6 (S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester 

Downstream Products

• 127605-44-1 (S)-homophenylalanine hydrobromide 
• 60425-49-2 (+)-α-amino-4-phenylbutyric acid methyl ester hydrochloride 

Relevant academic research and scientific papers

The invention of radical reactions. Part XXV. A convenient method for the synthesis of the acyl derivatives of N-hydroxypyridine-2-thione

Treatment of the readily available di-N-oxide - of 2-thiopyridine disulfide 6 with tributylphosphine in the presence of a carboxylic acid provides a convenient and high yielding synthesis of the acyl derivatives 2 of N-hydroxy-2-thio-pyridone. Application of this procedure to the acids 17 and 18 gave, after irradiation in the presence of t-butylthill, the desired decarboxylated derivatives in high (>90%) yield.

Non-Proteinogenic Amino Acid Synthesis. The β-Anion Derived from Aspartic Acid, and its Application to α-Amino Acid Synthesis.

Treatment of α-t-butyl β-methyl N-Z-(S)-aspartate (2) with lithium amide bases generates the corresponding β-ester enolate, which can be alkylated with suitable electrophiles.The application of this strategy for synthesis of optically active amino acids h