60425-49-2

Basic information

• Product Name: (αS)-α-AMino-benzenebutanoic Acid Methyl Ester Hydrochloride
• Synonyms: (αS)-α-AMino-benzenebutanoic Acid Methyl Ester Hydrochloride;L-HoMophenylalanine Methyl Ester Hydrochloride;H-HoPhe-OMe·HCl;(alphaS)-alpha-Aminobenzenebutanoic acid methyl ester hydrochloride
• CAS NO: 60425-49-2
• Molecular Formula: C₁₁H₁₅NO₂*ClH
• Molecular Weight: 229.70324
• Product Categories: Amino Acids & Derivatives;Aromatics;Chiral Reagents
• Mol File: 60425-49-2.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (αS)-α-AMino-benzenebutanoic Acid Methyl Ester Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (αS)-α-AMino-benzenebutanoic Acid Methyl Ester Hydrochloride(60425-49-2)
• EPA Substance Registry System: (αS)-α-AMino-benzenebutanoic Acid Methyl Ester Hydrochloride(60425-49-2)

Safety Data

• Hazardous Substances Data: 60425-49-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 110755-51-6 L-N-Boc-homophenylalanine amide 
• 106860-17-7 methyl 2S-2-amino-4-phenylbutanoate 
• 82795-51-5 D-homophenylalanine 
• 82732-07-8 Boc-L-homophenylalanine 
• 943-73-7 D-homophenylalanine 
• 127605-53-2 t-butyl N-Z-(S)-homophenylalanine 
• 123975-52-0 t-butyl 2-benzyloxycarbonylamino-3-carbomethoxy-4-phenyl-(2S)-butanoate 
• 144787-22-4 t-butyl 2-benzyloxycarbonylamino-3-carboxy-4-phenyl-(2S)-butanoate 
• 100-39-0 benzyl bromide 
• 80887-22-5 2-Acetylamino-2-phenethyl-malonic acid monoethyl ester 
• 141289-30-7 N-acetyl-DL-homophenylalanine ethyl ester 
• 103-63-9 1-phenyl-2-bromoethane 
• 96613-91-1 (R)-2-Acetamido-4-phenylbutansaeure 

Downstream Products

• 1131010-46-2 N-(homophenylalanine methyl ester)-1-(2,4-dichloropheny)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide 
• 1050310-91-2 (S)-2-{3-(cyclopropylmethyl)-3-[2-(hydroxyamino)-2-oxoethyl]ureido}-N-methyl-4-phenylbutanamide 
• 1050310-89-8 (S)-2-{3-[2-(hydroxyamino)-2-oxoethyl]-3-isobutylureido}-N-methyl-4-phenylbutanamide 
• 1050311-00-6 (S)-methyl 2-{1-isobutyl-3-[1-(methylamino)-1-oxo-4-phenylbutan-2-yl]ureido}acetate 
• 1433200-63-5 N-(L-phenylalanine methyl ester)-N’-(pyridin-4-ylmethyl)oxalamide 
• 1433200-61-3 N-(L-phenylalanine methyl ester)-N’-(pyridin-3-ylmethyl)oxalamide 

Relevant articles and documents

Ribose conversion with amino acids into pyrraline platform chemicals-expeditious synthesis of diverse pyrrole-fused alkaloid compounds

One-pot conversion of sustainable d-ribose with l-amino acid, methyl esters produced pyrrole-2-carbaldehydes 5 in reasonable yields (32-63%) under pressurized conditions of 2.5 atm at 80 °C. The value-added pyrraline compounds 5 as platform chemicals were utilized for quick installation of poly-heterocyclic cores for the development of pyrrole-motif natural and artificial therapeutic agents. A pyrrole-fused piperazin-2-one scaffold 6 was prepared by reductive amination of pyrralines 5 with benzylamine. While further cyclization of pyrralines 5 with ethane-1,2-diamine produced pyrrolo-piperazin-2-ones 7 with an extra imidazolidine ring, the reaction with 2-amino alcohols derived from natural l-amino acids, alanine, valine, and phenylalanine, respectively provided pyrrolo-piperazin-2-ones 8, 9, and 10 with oxazolidine as the third structural core. Cell viability and an anti-inflammatory effect of the synthesized compounds were briefly tested by the MTT method and the Griess assay, among which 8h and 10g exhibited significant anti-inflammatory effects with negligible cell toxicity.

Substituted Dihydroisoquinolinones by Iodide-Promoted Cyclocarbonylation of Aromatic α-Amino Acids

Imidazolidinone derivatives of a range of aromatic α-amino acids, on treatment with phosgene and potassium iodide, undergo a mild Bischler-Napieralski-style cyclocarbonylation reaction that generates a tricyclic lactam by insertion of a C=O group between amino acid nitrogen and the ortho position of the aryl substituent. Regio- and diastereoselective functionalization of the lactam generates a library of substituted dihydroisoquinolinones and their congeners in enantioenriched form.

CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING OBESITY

The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity, diabetes, and/or cardiometabolic disorders.