1276113-33-7

Upstream product

• 1276113-32-6 (2-bromo-4-(((tert-butyldimethylsilyl)oxy)methyl)phenoxy)(tert-butyl)dimethylsilane 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 
• 29922-56-3 2-bromo-4-(hydroxymethyl)phenol 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 29415-97-2 methyl 3-bromo-4-hydroxybenzoate 

Relevant academic research and scientific papers

Enantioselective total synthesis and absolute configuration of the alleged structure of crassinervic acid

An enantioselective synthesis of the structure reported for the natural antifungal compound, (-)-crassinervic acid (1), has been achieved starting from geraniol and p-hydroxybenzoic acid. The key chirality-inducing step is a Sharpless asymmetric epoxidation of an allylic alcohol, on the basis of which the S configuration can be assigned to the (-) natural enantiomer. The discrepancies between the spectroscopic data for synthetic and natural crassinervic acid cast some doubts on the structure assigned to the natural compound. A possible revised structure is discussed.

A domino process for benzyne preparation: Dual activation of o-(trimethylsilyl)phenols by nonafluorobutanesulfonyl fluoride

Benzynes were generated from o-(trimethylsilyl)phenols using nonafluorobutanesulfonyl fluoride (NfF) by a domino process, i.e., the nonaflation of the phenolic hydroxyl group of o-(trimethylsilyl)phenols by NfF followed by the attack of the produced fluoride ion on the trimethylsilyl group. The generated benzyne immediately underwent various reactions to give polysubstituted benzenes.