1276118-81-0Relevant articles and documents
Umpolung of Imines Enables Catalytic Asymmetric Regio-reversed [3+2] Cycloadditions of Iminoesters with Nitroolefins
Feng, Bin,Lu, Liang-Qiu,Chen, Jia-Rong,Feng, Guoqiang,He, Bin-Qing,Lu, Bin,Xiao, Wen-Jing
supporting information, p. 5888 - 5892 (2018/05/14)
A copper-catalyzed regio-reversed asymmetric [3+2] cycloaddition of iminoesters with nitroolefins is disclosed for the first time. This method enables the facile synthesis of polysubstituted chiral pyrrolidines bearing at least one chiral quaternary cente
Novel analogues of ketamine and phencyclidine as NMDA receptor antagonists
Zarantonello, Paola,Bettini, Ezio,Paio, Alfredo,Simoncelli, Chiara,Terreni, Silvia,Cardullo, Francesco
scheme or table, p. 2059 - 2063 (2011/04/24)
The identification of structurally novel analogues of ketamine and phencyclidine (PCP), as NMDA receptor antagonists, with low to moderate potency at GluN2A and GluN2B receptors is discussed. In particular, some examples, such as compounds 6 and 10, shows decreased calculated lipophilicity, when compared to PCP, while retaining moderate activity. Moreover, the germinal aryl amino substituted lactam ring, as exemplified in compounds 7-10 and 11-13, constitutes a novel scaffold with potential application in the design of biologically active compounds.
