1276183-95-9Relevant academic research and scientific papers
Highly Diastereo- and Enantioselective Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Myoglobin-Catalyzed Transfer of Trifluoromethylcarbene
Tinoco, Antonio,Steck, Viktoria,Tyagi, Vikas,Fasan, Rudi
, p. 5293 - 5296 (2017)
We report an efficient strategy for the asymmetric synthesis of trifluoromethyl-substituted cyclopropanes by means of myoglobin-catalyzed olefin cyclopropanation reactions in the presence of 2-diazo-1,1,1-trifluoroethane (CF3CHN2) as
Highly enantioselective synthesis of trifluoromethyl cyclopropanes by using Ru(ii)-Pheox catalysts
Kotozaki, Manato,Chanthamath, Soda,Fujii, Takuji,Shibatomi, Kazutaka,Iwasa, Seiji
, p. 5110 - 5113 (2018)
An asymmetric synthesis of various trifluoromethyl cyclopropanes from olefins, such as vinyl ferrocene, vinyl ethers, vinyl amines, vinyl carbamates and dienes, was achieved by using Ru(ii)-Pheox catalysts. This catalytic system can function at a low catalyst loading (3 mol%) compared with those reported previously, and the desired cyclopropane products are obtained in high yields with excellent diastereoselectivity (up to >99:1) and enantioselectivity (up to 97% ee).
Enantioselective cobalt-catalyzed preparation of trifluoromethyl- substituted cyclopropanes
Morandi, Bill,Mariampillai, Brian,Carreira, Erick M.
supporting information; experimental part, p. 1101 - 1104 (2011/04/21)
Easy access on water: A cobalt-catalyzed asymmetric preparation of trifluoromethylcyclopropanes has been developed that yields high enantioselectivities with a broad range of styrene substrates (see scheme). The reaction presents a new access to enantioen
