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127641-07-0

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127641-07-0 Usage

General Description

2,5-Diazabicyclo[2.2.1]heptane,2-(phenylmethyl)-,(1S,4S)-(9CI) is a chemical compound that has a bicyclic structure and a phenylmethyl group attached to it. It is also known as (1S,4S)-2-phenylmethylpiperazine and is used as a chiral ligand in various catalytic reactions. 2,5-Diazabicyclo[2.2.1]heptane,2-(phenylmethyl)-,(1S,4S)-(9CI) has been studied for its potential applications in asymmetric synthesis and as a resolving agent for racemic mixtures. It is also known for its ability to form complexes with metal ions, which can be used in different chemical transformations. Overall, 2,5-Diazabicyclo[2.2.1]heptane,2-(phenylmethyl)-,(1S,4S)-(9CI) is an important compound in the field of organic chemistry and has a wide range of potential applications in the synthesis of chiral molecules.

Check Digit Verification of cas no

The CAS Registry Mumber 127641-07-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,6,4 and 1 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 127641-07:
(8*1)+(7*2)+(6*7)+(5*6)+(4*4)+(3*1)+(2*0)+(1*7)=120
120 % 10 = 0
So 127641-07-0 is a valid CAS Registry Number.

127641-07-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,5-Diazabicyclo[2.2.1]heptane,2-(phenylmethyl)-,(1S,4S)-(9CI)

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127641-07-0 SDS

127641-07-0Relevant articles and documents

Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation

Pismataro, Maria Chiara,Horenstein, Nicole A.,Stokes, Clare,Quadri, Marta,De Amici, Marco,Papke, Roger L.,Dallanoce, Clelia

supporting information, (2020/08/19)

The α7 nicotinic acetylcholine receptor (nAChR) silent agonists, able to induce receptor desensitization and promote the α7 metabotropic function, are emerging as new promising therapeutic anti-inflammatory agents. Herein, we report the structure–activity

Multicomponent synthesis of some new (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-dithiocarbamates and their in vitro anti-proliferative activity against CaSki, MDA-MB-231 and SK-Lu-1 tumour cells as apoptosis inducing agents without necrosis

Laskar, Sujay,Sánchez-Sánchez, Luis,López-Ortiz, Manuel,López-Mu?oz, Hugo,Escobar-Sánchez, María L.,Sánchez, Arturo T.,Regla, Ignacio

, p. 1129 - 1135 (2017/09/18)

Identification of a new class of antitumor agent capable to induce apoptosis without triggering necrotic cell death event is challenging. The present communication describes the multicomponent synthesis of seven new (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-dithiocarbamates and their in vitro antiproliferative activity on cervical cancer cell line (CaSki), breast cancer cell line (MDA-MB231), lung cancer cell line (SK-Lu-1) and human lymphocytes. Among the synthesized dithiocarbamates, compound 9e displayed significant antiproliferative activity without inducing any necrotic cell death (both on tumour cells and lymphocytes) and induced apoptosis in tumor cells by the caspase dependent apoptotic pathway. The compound 9e also exhibited greater tumor selectivity than human lymphocytes. In silico ADME predictions revealed that compound 9e has the potential to be developed as a drug candidate. Rapid chemical modifications of this lead are thus highly necessary for further investigation as a drug like safer antitumor candidate and also to achieve compounds with better activity profile.

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