141850-60-4

Basic information

• Product Name: (2S,4R)-(1-tosyl-4-(tosyloxy)pyrrolidin-2-yl)methyl 4-methylbenzenesulfonate
• Synonyms: (2S,4R)-(1-tosyl-4-(tosyloxy)pyrrolidin-2-yl)methyl 4-methylbenzenesulfonate
• CAS NO: 141850-60-4
• Molecular Weight: 425.527
• Mol File: 141850-60-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S,4R)-(1-tosyl-4-(tosyloxy)pyrrolidin-2-yl)methyl 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-(1-tosyl-4-(tosyloxy)pyrrolidin-2-yl)methyl 4-methylbenzenesulfonate(141850-60-4)
• EPA Substance Registry System: (2S,4R)-(1-tosyl-4-(tosyloxy)pyrrolidin-2-yl)methyl 4-methylbenzenesulfonate(141850-60-4)

Safety Data

• Hazardous Substances Data: 141850-60-4(Hazardous Substances Data)

Upstream product

• 57850-05-2 (2S,4R)-2-Hydroxymethyl-4-hydroxy-1-(4-toluenesulfonyl)-pyrrolidine 
• 98-59-9 p-toluenesulfonyl chloride 
• 51-35-4 4R-4-hydroxyproline 
• 20275-18-7 N--trans-4-hydroxy-L-proline 

Downstream Products

• 141850-21-7 Hept-6-enoic acid (3R,5S)-1-(toluene-4-sulfonyl)-5-(toluene-4-sulfonyloxymethyl)-pyrrolidin-3-yl ester 
• 141850-28-4 (R)-5-Methylene-1-(toluene-4-sulfonyl)-pyrrolidin-3-ol 
• 141850-27-3 (1R,11S)-12-(Toluene-4-sulfonyl)-2,9-dioxa-12-aza-bicyclo[9.2.1]tetradecane-3,8-dione 
• 141850-61-5 Hexanedioic acid mono-[(3R,5S)-5-iodomethyl-1-(toluene-4-sulfonyl)-pyrrolidin-3-yl] ester 
• 141850-22-8 Hexanedioic acid mono-[(3R,5S)-1-(toluene-4-sulfonyl)-5-(toluene-4-sulfonyloxymethyl)-pyrrolidin-3-yl] ester 
• 1070246-13-7 methyl (2S,4R)-4-hydroxy-1-[((2S,4R)-1-p-tosyl-4-hydroxypyrrolidin-2-yl)methyl]pyrrolidine-2-carboxylate 
• 5234-72-0 (1S,4S)-5-Benzyl-2-tosyl-2,5-diazabicyclo<2.2.1>heptane 
• 127641-07-0 (1S,4S)-N-Benzyl-2,5-diazabicyclo-[2.2.1]heptane 

Relevant articles and documents

Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation

The α7 nicotinic acetylcholine receptor (nAChR) silent agonists, able to induce receptor desensitization and promote the α7 metabotropic function, are emerging as new promising therapeutic anti-inflammatory agents. Herein, we report the structure–activity

Synthesis of Macrocyclic Dilactones by Cyclization of Sulfonium Salts

An efficient method for the formation of macrocyclic dilactones via cyclization of (ω-carboxyalkyl)diphenylsulfonium salts 3 containing an ester linkage under mild conditions is described.These sulfonium salts 3 were cyclized in the presence of cesium carbonate under high-dilution conditions to give 11- to 16-membered dilactones 4 in good yields.The cyclization of sulfonium salt 22 was successfully carried out for the synthesis of 11-membered dilactonic pyrrolizidine alkaloid, 13,13-dimethyl-1,2-didehydrocrotalanine 23.