141850-60-4

Upstream product

• 20275-18-7 N--trans-4-hydroxy-L-proline 
• 98-59-9 p-toluenesulfonyl chloride 
• 51-35-4 4R-4-hydroxyproline 
• 57850-05-2 (2S,4R)-2-Hydroxymethyl-4-hydroxy-1-(4-toluenesulfonyl)-pyrrolidine 

Downstream Products

• 1070246-13-7 methyl (2S,4R)-4-hydroxy-1-[((2S,4R)-1-p-tosyl-4-hydroxypyrrolidin-2-yl)methyl]pyrrolidine-2-carboxylate 
• 5234-72-0 (1S,4S)-5-Benzyl-2-tosyl-2,5-diazabicyclo<2.2.1>heptane 
• 127641-07-0 (1S,4S)-N-Benzyl-2,5-diazabicyclo-[2.2.1]heptane 
• 141850-22-8 Hexanedioic acid mono-[(3R,5S)-1-(toluene-4-sulfonyl)-5-(toluene-4-sulfonyloxymethyl)-pyrrolidin-3-yl] ester 
• 141850-61-5 Hexanedioic acid mono-[(3R,5S)-5-iodomethyl-1-(toluene-4-sulfonyl)-pyrrolidin-3-yl] ester 
• 141850-27-3 (1R,11S)-12-(Toluene-4-sulfonyl)-2,9-dioxa-12-aza-bicyclo[9.2.1]tetradecane-3,8-dione 
• 141850-28-4 (R)-5-Methylene-1-(toluene-4-sulfonyl)-pyrrolidin-3-ol 
• 141850-21-7 Hept-6-enoic acid (3R,5S)-1-(toluene-4-sulfonyl)-5-(toluene-4-sulfonyloxymethyl)-pyrrolidin-3-yl ester 

Relevant academic research and scientific papers

Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation

The α7 nicotinic acetylcholine receptor (nAChR) silent agonists, able to induce receptor desensitization and promote the α7 metabotropic function, are emerging as new promising therapeutic anti-inflammatory agents. Herein, we report the structure–activity

Synthesis and application of novel proline-derived chiral piperazinones and sulfamide-amine alcohols

Several novel chiral piperazinone and sulfamide-amine alcohols were synthesized starting from inexpensive and readily available L-proline and trans-4-hydroxy-L-proline. The catalytic activity of the sulfamide-amine alcohols for the asymmetric addition of diethylzinc to benzaldehyde were evaluated preliminarily. Copyright Taylor & Francis Group, LLC.

Synthesis of Macrocyclic Dilactones by Cyclization of Sulfonium Salts

An efficient method for the formation of macrocyclic dilactones via cyclization of (ω-carboxyalkyl)diphenylsulfonium salts 3 containing an ester linkage under mild conditions is described.These sulfonium salts 3 were cyclized in the presence of cesium carbonate under high-dilution conditions to give 11- to 16-membered dilactones 4 in good yields.The cyclization of sulfonium salt 22 was successfully carried out for the synthesis of 11-membered dilactonic pyrrolizidine alkaloid, 13,13-dimethyl-1,2-didehydrocrotalanine 23.