1276542-98-3

Basic information

• Product Name: 2-amino-1-(4-fluorophenyl)-4-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile
• CAS NO: 1276542-98-3
• Molecular Weight: 547.607
• Mol File: 1276542-98-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-1-(4-fluorophenyl)-4-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-1-(4-fluorophenyl)-4-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile(1276542-98-3)
• EPA Substance Registry System: 2-amino-1-(4-fluorophenyl)-4-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile(1276542-98-3)

Safety Data

• Hazardous Substances Data: 1276542-98-3(Hazardous Substances Data)

Upstream product

• 1994-40-7 1-(1-(4-fluorophenyl)ethylidene)-2-phenylhydrazine 
• 371-40-4 4-fluoroaniline 
• 100445-51-0 3-[(4-fluorophenyl)amino]-5,5-dimethylcyclohex-2-en-1-one 
• 109-77-3 malononitrile 
• 36640-40-1 3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 
• 100-63-0 phenylhydrazine 
• 126-81-8 dimedone 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Relevant articles and documents

Synthesis and antimicrobial activity of some new N-substituted quinoline derivatives of 1H-pyrazole

A new series of 32 derivatives of 4-pyrazolyl-N-(hetero)arylquinoline 5a-p and 6a-p were synthesized by a one-pot base-catalyzed cyclocondensation reaction of 1-phenyl-3-(hetero)aryl-pyrazole-4-carbaldehyde 1a-h, malononitrile 2, and 3-(hetero)aryl-5,5-disubstitutedcyclohex-2-enone 3a-b or 4a-b, respectively. All the synthesized compounds were characterized by elemental analysis, FT-IR, 1H-NMR, and 13C-NMR spectral data. All the synthesized compounds were screened, against six bacterial pathogens, namely Bacillus subtilis, Clostridium tetani, Streptococcus pneumoniae, Salmonella typhi, Vibrio cholerae, Escherichia coli, and antifungal activity, against two fungal pathogens Aspergillus fumigatus and Candida albicans, using broth microdilution MIC method. Some of the compounds were found to be more or equipotent against most of the employed strains than commercially available drugs as evident from the screening data. Quinoline derivatives are known to exhibit a wide range of biological activities. Therefore, a series of some new 1,4-di(hetero)aryl quinoline derivatives bearing a 1H-pyrazole nucleus have been synthesized and were evaluated for their antimicrobial activities against a panel of human pathogens. Copyright