127660-88-2

Basic information

• Product Name: N-(Cyclohexylmethyl)-N-(p-tolyl)amine
• Synonyms: N-(Cyclohexylmethyl)-N-(p-tolyl)amine
• CAS NO: 127660-88-2
• Molecular Weight: 203.327
• Mol File: 127660-88-2.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: N-(Cyclohexylmethyl)-N-(p-tolyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(Cyclohexylmethyl)-N-(p-tolyl)amine(127660-88-2)
• EPA Substance Registry System: N-(Cyclohexylmethyl)-N-(p-tolyl)amine(127660-88-2)

Safety Data

• Hazardous Substances Data: 127660-88-2(Hazardous Substances Data)

Upstream product

• 53185-69-6 pimelaldehyde 
• 106-49-0 p-toluidine 
• 191664-04-7 4-Chloro-benzenesulfonic acid cyclohexylmethyl ester 
• 201230-82-2 carbon monoxide 
• 110-83-8 cyclohexene 
• 32328-79-3 4-methyl-N-methyleneaniline 
• 110-82-7 cyclohexane 
• 623-08-5 N-methyl-p-toluidine 
• 5720-05-8 4-methylphenylboronic acid 
• 3217-92-3 N-(cyclohexylmethyl)hydroxylamine 
• 4715-11-1 cyclohexanecarbaldoxime 
• 2043-61-0 cyclohexanecarbaldehyde 
• 189161-99-7 N-(cyclohexylmethylene)-4-methylaniline 
• 100-49-2 cyclohexylmethyl alcohol 

Downstream Products

• 189161-99-7 N-(cyclohexylmethylene)-4-methylaniline 

Relevant articles and documents

Heterogeneous Ru/TiO2for hydroaminomethylation of olefins: multicomponent synthesis of amines

Synthesizing aminesviathe hydroaminomethylation (HAM) reaction of olefins, a multicomponent reaction, has been regarded as one of the most attractive methods compared with the traditional methods considering the atom economy and environmental friendliness. However, the use of homogeneous catalysts, complex ligands containing diphosphine or nitrogen, and base or acid additives has severely hampered the utilization of these methods. Herein, an efficient heterogeneous Ru/TiO2-catalyzed HAM reaction of olefins is developed without any additives. Various amines, including secondary and tertiary amines, can be successfully obtained from olefins including aromatic and aliphatic olefins. Systematic studies demonstrate the lower electron density of Ruδ+and the higher number of acid sites of Ru/TiO2, leading to the high HAM reaction activity of olefins. Most importantly, nitrobenzene derivatives can also be transformed to the corresponding products over Ru/TiO2in excellent yields.

Dehydrogenation and α-functionalization of secondary amines by visible-light-mediated catalysis

A visible-light-mediated process for dehydrogenation of amines has been described. The given protocol showed a broad substrate scope, mild reaction conditions and excellent results without the requirement of tedious purification. This process can be applied in one-pot functionalization of secondary amines with various nucleophiles through the cooperation of visible-light and Lewis acid catalysis, leading to the structurally varied essential components of biologically active molecules. In addition, Stern-Volmer studies and quenching experiments revealed the role of a catalyst and led to the proposed mechanism of this transformation.

Metal- and Base-Free Room-Temperature Amination of Organoboronic Acids with N-Alkyl Hydroxylamines

We have found that readily available N-alkyl hydroxylamines are effective reagents for the amination of organoboronic acids in the presence of trichloroacetonitrile. This amination reaction proceeds rapidly at room temperature and in the absence of added metal or base, it tolerates a remarkable range of functional groups, and it can be used in the late-stage assembly of two complex units.