1276668-07-5

Basic information

• Product Name: methyl (2S,3S)-2-{4'-[(4-aminophenyl)buta-1',3'-diynyl]benzamido}-3-hydroxybutanoate
• Synonyms: methyl (2S,3S)-2-{4'-[(4-aminophenyl)buta-1',3'-diynyl]benzamido}-3-hydroxybutanoate
• CAS NO: 1276668-07-5
• Molecular Weight: 376.412
• Mol File: 1276668-07-5.mol

Chemical Properties

• CAS DataBase Reference: methyl (2S,3S)-2-{4'-[(4-aminophenyl)buta-1',3'-diynyl]benzamido}-3-hydroxybutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2S,3S)-2-{4'-[(4-aminophenyl)buta-1',3'-diynyl]benzamido}-3-hydroxybutanoate(1276668-07-5)
• EPA Substance Registry System: methyl (2S,3S)-2-{4'-[(4-aminophenyl)buta-1',3'-diynyl]benzamido}-3-hydroxybutanoate(1276668-07-5)

Safety Data

• Hazardous Substances Data: 1276668-07-5(Hazardous Substances Data)

Upstream product

• 728878-27-1 4-[(4'-aminophenyl)buta-1,3-diyn-1-yl]benzoic acid 
• 39994-75-7 (L)-allo-threonine methyl ester hydrochloride 
• 119984-88-2 methyl 4-[(4'-aminophenyl)buta-1,3-diyn-1-yl]benzoate 
• 619-44-3 methyl 4-iodobenzoate 
• 3034-86-4 4-ethynylbenzoic acid methyl ester 
• 75867-41-3 4-trimethylsilanylethynyl-benzoic acid methyl ester 

Downstream Products

• 728877-74-5 4-[4-(4-aminophenyl)buta-1,3-diynyl]-N-{(1S,2S)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}benzamide 

Relevant articles and documents

ETHYNYLBENZENE DERIVATIVES

Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.

Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold

Compounds inhibiting LpxC in the lipid A biosynthetic pathway are promising leads for novel antibiotics against multidrug-resistant Gram-negative pathogens. We report the syntheses and structural and biochemical characterizations of LpxC inhibitors based on a diphenyl-diacetylene (1,4-diphenyl-1,3-butadiyne) threonyl-hydroxamate scaffold. These studies provide a molecular interpretation for the differential antibiotic activities of compounds with a substituted distal phenyl ring as well as the absolute stereochemical requirement at the C2, but not C3, position of the threonyl group.