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4-[(4'-aminophenyl)buta-1,3-diyn-1-yl]benzoic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

728878-27-1

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728878-27-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 728878-27-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,2,8,8,7 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 728878-27:
(8*7)+(7*2)+(6*8)+(5*8)+(4*7)+(3*8)+(2*2)+(1*7)=221
221 % 10 = 1
So 728878-27-1 is a valid CAS Registry Number.

728878-27-1Relevant articles and documents

HYDROXYPYRIDINONE AND HYDROXYPYRIMIDINONE BASED COMPOUNDS FOR TREATING BACTERIAL INFECTIONS

-

, (2017/06/22)

The present teachings relate to hydroxypyridinone and hydroxypyrimidinone derivatives, pharmaceutical compositions thereof, and methods of using such compounds to treat bacterial infections.

BENZOYLGLYCINE DERIVATIVES AND METHODS OF MAKING AND USING SAME

-

, (2017/12/15)

Disclosed are compounds of formulae: and pharmaceutically acceptable salts thereof, wherein the variables, R1,R2, R3, R4, R5, R6, R7, R11, R12, R13/su

A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058

Liang, Xiaofei,Gopalaswamy, Ramesh,Navas, Frank,Toone, Eric J.,Zhou, Pei

, p. 4393 - 4398 (2016/06/09)

The difluoromethyl-allo-threonyl hydroxamate-based compound LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) in Gram-negative bacteria. A scalable synthesis of this compound is described. The key step

ETHYNYLBENZENE DERIVATIVES

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, (2012/03/26)

Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.

Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold

Liang, Xiaofei,Lee, Chul-Jin,Chen, Xin,Chung, Hak Suk,Zeng, Daina,Raetz, Christian R.H.,Li, Yaoxian,Zhou, Pei,Toone, Eric J.

, p. 852 - 860 (2011/03/19)

Compounds inhibiting LpxC in the lipid A biosynthetic pathway are promising leads for novel antibiotics against multidrug-resistant Gram-negative pathogens. We report the syntheses and structural and biochemical characterizations of LpxC inhibitors based on a diphenyl-diacetylene (1,4-diphenyl-1,3-butadiyne) threonyl-hydroxamate scaffold. These studies provide a molecular interpretation for the differential antibiotic activities of compounds with a substituted distal phenyl ring as well as the absolute stereochemical requirement at the C2, but not C3, position of the threonyl group.

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