127667-00-9

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-5-METHOXYBENZONITRILE is used as a chemical intermediate for the synthesis of pharmaceuticals, contributing to the development of new medications due to its unique molecular structure and reactivity.
Used in Agricultural Chemical Industry:
Similarly, in the agricultural chemical sector, 2-CHLORO-5-METHOXYBENZONITRILE serves as an intermediate, playing a crucial role in the production of agrochemicals that are vital for crop protection and enhancement of agricultural yields.
Used as a Building Block in Organic Compounds Production:
Beyond its applications in pharmaceuticals and agrochemicals, 2-CHLORO-5-METHOXYBENZONITRILE is also utilized as a building block in the creation of other organic compounds, highlighting its versatility in organic synthesis and the potential for diverse applications across various industries.
Safety and Handling:
Given its potential health and environmental hazards, 2-CHLORO-5-METHOXYBENZONITRILE should be handled and stored following good laboratory practices to ensure the safety of both individuals and the environment.

InChI:InChI=1/C8H6ClNO/c1-11-7-2-3-8(9)6(4-7)5-10/h2-4H,1H3

Upstream product

• 2401-24-3 2-chloro-5-methoxyaniline 
• 544-92-3 copper(I) cyanide 
• 13719-61-4 2-chloro-5-methoxybenzaldehyde 
• 623-12-1 4-chloromethoxybenzene 
• 1146731-96-5 C₉H₁₀ClNO₂ 

Downstream Products

• 127667-11-2 2-(Cyano-phenyl-methyl)-5-methoxy-benzonitrile 
• 951625-95-9 2-chloro-5-methoxybenzimidamide 

Relevant academic research and scientific papers

A method for the preparation of oxadiazole compounds (by machine translation)

The invention discloses a oxadiazole compound N - ((3 - (2 - chloro - 5 - methoxyphenyl) - 1, 2, 4 - oxadiazol - 5 - yl) methyl) aminoethane preparation method, in order to 4 - chlorophenyl methyl ether as the starting material, through the aldehyde group, oximation, eliminate, addition, ring, substituted reaction to obtain the target product 7, the product of the invention as the template molecule to synthesize a variety of compound library. (by machine translation)

Ruthenium-catalyzed intramolecular selective halogenation of O-methylbenzohydroximoyl halides: A new route to halogenated aromatic nitriles

The intramolecular halogenation of O-methylbenzohydroximoyl halides in the presence of a Ru catalyst and the ligand diphenylacetylene afforded halo substituted aromatic nitriles in a highly regioselective manner. Further, substituted nitriles were converted into substituted tetrazole derivatives in the presence of NaN3 and I2.

Displacement of Halogen of 2-Halogeno-Substituted Benzonitriles with Carbanions. Preparation of (2-Cyanoaryl)arylacetonitriles

(2-Cyanoaryl)arylacetonitriles are obtained by displacement of halogen of 2-halobenzonitriles with phenylacetonitrile anions.The method also applies to a number of heteroaromatics with ortho-situated halogen and cyano groups and to heteroarylacetonitrile anions.The anions were generated by using potassium tert-butoxide or potassium carbonate.Calculated electron densities of the electrophilic centers reflect the reactivity in the displacement reaction.The calculations indicate that the potassium ion complexes with the cyano group of the 2-halobenzonitriles in nonpolar solvents, thus promoting competitive addition of the anion to the cyano group.Carbanions derived from acids with pKa ca. 19-23 similarly displaced the halogen of 2-halobenzonitriles.