127682-75-1

Upstream product

• 127682-82-0 (2R-cis)-4-(6-chloro-9H-purin-9-yl)-tetrahydro-2-furanmethanol 
• 127682-78-4 (2R-trans)-tetrahydro-4-[[(4-methylphenyl)-sulfonyl]oxy]-2-furanmethanol 
• 66224-66-6 adenine 
• 75-09-2 dichloromethane 
• 584-08-7 potassium carbonate 
• 127682-81-9 (2R-cis)-4-[(5-amino-6-chloro-4-pyrimidinyl)-amino]tetrahydro-2-furanmethanol 
• 127682-76-2 (2R,4S)-4-hydroxy-2-dimethoxymethyltetrahydrofuran 
• 127682-80-8 (2R-cis)-4-aminotetrahydro-2-furanmethanol 
• 3396-72-3 3-deoxy-1,2-O-(1-methylethylidene)-α-D-erythro-pentofuranose 4-methylbenzenesufonate 
• 38166-60-8 1,2:5,6-di-O-isopropylidene-α-L-glucofuranoside 
• 100638-80-0 1,2:5,6-di-O-isopropylidene-3-O-(methylthio)thiocarbonyl-β-D-idose 
• 163956-65-8 methyl 5-O-benzyl-3-deoxy-L-erythro-pentofuranoside 
• 4613-68-7 (3aS,5R,6aS)-2,2-Dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole-5-carbaldehyde 
• 4005-46-3 3-deoxy-1,2-O-isopropylidene-α-L-glucose 

Relevant academic research and scientific papers

SYNTHESYS OF ISO-DDA, MEMBER OF A NOVEL CLASS OF ANTI-HIV AGENTS

Iso-ddA (3) represents a new class of potential anti-AIDS drugs.Synthetic approaches to this compound involving nucleophilic additions to a novel carbohydrate framework are discussed.

Synthesis and Evaluation of the Anti-HIV Activity of Aza and Deaza Analogues of IsoddA and Their Phosphates as Prodrugs

Some aza and deaza analogues of the anti-HIV agent 2',3'-dideoxy-3'-oxoadenosine (isoddA) (8-aza-, 8-aza-1-deaza-, 8-aza-3-deaza-, 1-deaza-, and 3-deaza-isoddA) were synthesized and found inactive against HIV in vitro.The hypothesis that the inactivity of

Enantiospecific total synthesis of L-2',3'-dideoxyisonucleosides via regioselective opening of optically active C2-symmetric 1,4-pentadiene bis- epoxide

A new method for the synthesis of L-2',3'-dideoxyisonucleosides is described. The readily available, optically active C2-symmetric bis-epoxide (2S,4S)-1,2:4,5-diepoxypentane (5) was prepared by a short route from readily available starting mate

Isomeric dideoxynuclesides

Isomeric derivatives of 2',3'-dideoxyadenosine and 2',3'-dideoxyguanosine wherein the adenine or guanine base is attached to the 1' position of the iso-dideoxysugar residue by the 9-N position, the novel intermediates used in the synthesis of these compounds, and a method for treating a subject infected with a retrovirus by administering the compounds of the invention.

Enantiospecific Synthesis of 3'-Hetero-dideoxy Nucleoside Analogues as Potential Anti-HIV Agents

Two series of analogues of 2',3'-dideoxy carbocyclic nucleosides, in which the 3'-carbon atom is replaced by either an oxygen or a sulfur atom, have been prepared enantiospecifically from diacetone-L-glucose and diacetone-D-glucose respectively.Within eac