Synthesis and Evaluation of the Anti-HIV Activity of Aza and Deaza Analogues of IsoddA and Their Phosphates as Prodrugs

DOI: 10.1021/jm00047a011

Source and publish data:

Journal of Medicinal Chemistry p. 3534 - 3541 (1994)

Update date:2022-08-10

Topics:

Authors:

Franchetti, Palmarisa

Cappellacci, Loredana

Grifantini, Mario

Messini, Lea

Sheikha, Ghassan Abu

et al. et al.

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Article abstract of DOI:10.1021/jm00047a011

Some aza and deaza analogues of the anti-HIV agent 2',3'-dideoxy-3'-oxoadenosine (isoddA) (8-aza-, 8-aza-1-deaza-, 8-aza-3-deaza-, 1-deaza-, and 3-deaza-isoddA) were synthesized and found inactive against HIV in vitro.The hypothesis that the inactivity of

Full text of DOI:10.1021/jm00047a011

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