127682-77-3

Upstream product

• 532-20-7 D-xylofuranose 
• 127682-76-2 (3R,5S)-5-Dimethoxymethyl-tetrahydro-furan-3-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 3396-72-3 3-deoxy-1,2-O-(1-methylethylidene)-α-D-erythro-pentofuranose 4-methylbenzenesufonate 
• 6022-96-4 5-O-benzoyl-α-D-xylofuranose 
• 20881-04-3 1,2:3,5-di-O-isopropylidene-D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 3396-71-2 3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose 
• 127682-76-2 (2R,4S)-4-hydroxy-2-dimethoxymethyltetrahydrofuran 

Downstream Products

• 127682-82-0 (2R-cis)-4-(6-chloro-9H-purin-9-yl)tetrahydrofuran-2-methanol 
• 127682-78-4 (2R-trans)-tetrahydro-4-<<(4-methylphenyl)sulfonyl>oxy>-2-furanmethanol 
• 127682-80-8 (2R-cis)-4-aminotetrahydro-2-furanmethanol 
• 127682-82-0 (2R-cis)-4-(6-chloro-9H-purin-9-yl)-tetrahydro-2-furanmethanol 
• 127682-78-4 (2R-trans)-tetrahydro-4-[[(4-methylphenyl)-sulfonyl]oxy]-2-furanmethanol 
• 127682-80-8 (2R-cis)-4-aminotetrahydro-2-furanmethanol 
• 127682-75-1 IsoddA 

Relevant academic research and scientific papers

New isomeric analogues of anti-HIV active azidonucleosides

Synthesis and antiviral studies of novel 2'-isomeric dideoxynucleosides of the D-related class are described. The target compounds are analogues of anti-HIV active 4'-azido-2'-deoxynucleosides.

THE SYNTHESIS OF (S) AND (R) ENANTIOMERS OF NOVEL HYDROXYMETHYLATED ISODIDEOXYNUCLEOSIDES

Novel isomeric dideoxynucleosides, with symmetry introduced at the 2'-position (4'-position using normal nucleoside numbernig) through the introduction of an additional hydroxymethyl group, have been synthesized.Both (R) and (S) enantiomeric series were investigated.The methodologies developed have generality and the presence of the hydroxymethyl group trans to the base may be used to introduce a wide variety of functionalities at this position.

Synthesis and anti-HIV activity of isonucleosides

A series of isomeric 2',3'-dideoxynucleosides which contains a modified carbohydrate moiety has been prepared. This class of compounds was designed to mimic the activity of known anti-HIV dideoxynucleosides, while imparting enhanced chemical and enzymatic

SYNTHESYS OF ISO-DDA, MEMBER OF A NOVEL CLASS OF ANTI-HIV AGENTS

Iso-ddA (3) represents a new class of potential anti-AIDS drugs.Synthetic approaches to this compound involving nucleophilic additions to a novel carbohydrate framework are discussed.